| 潘雪峰,高春芳.LncRNA PVT1与恶性肿瘤治疗的研究进展[J].肿瘤学杂志,2019,25(2):145-151. |
| LncRNA PVT1与恶性肿瘤治疗的研究进展 |
| Research Progress of LncRNA PVT1 in Cancer Therapy |
| 投稿时间：2017-12-06 |
| DOI：10.11735/j.issn.1671-170X.2019.02.B013 |
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| 中文关键词: 长链非编码RNA PVT1 肿瘤 治疗靶点 |
| 英文关键词:long non-coding RNA plasmacytoma variant translocation 1 neoplasm therapeutic target |
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| 中文摘要: |
| 摘 要：长链非编码RNA-PVT1（lncRNA PVT1）作为一种重要的致癌性非编码RNA在多种恶性肿瘤呈现高表达并提示不良预后，其通过影响肿瘤细胞的增殖、迁移、侵袭和凋亡促进肿瘤的发生发展。目前大量的研究表明lncRNA PVT1在多种肿瘤中具有致癌活性或驱动作用，比如以竞争性内源RNA或作为“分子海绵”负性调控肿瘤相关miRNA的表达促进肿瘤发生等，因此，基于lncRNA PVT1在肿瘤发病中的关键作用，进一步的深入研究有望为恶性肿瘤提供新的治疗靶点。 |
| 英文摘要: |
| Abstract：LncRNA PVT1 is an important carcinogenic long non-coding RNA，and the high expression of lncRNA PVT1 in malignant tumors suggests a poor prognosis. LncRNA PVT1 can promote the tumorigenesis and development of cancers by affecting cell proliferation，migration，invasion and apoptosis. Accumulating evidence has indicated that lncRNA PVT1，as a competing endogenous RNA or a molecular sponge，negatively modulates miRNA expression to promote the cancer development. Based on the critical role of lncRNA PVT1 in the pathogenesis of cancers，further study would provide a novel therapeutic target for various cancers in the future. |
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