| 毛燕娇,徐剑锋,尹 伟.外周血循环肿瘤细胞在49例鼻咽癌中表达[J].肿瘤学杂志,2019,25(2):97-101. |
| 外周血循环肿瘤细胞在49例鼻咽癌中表达 |
| Expression of Circulating Tumor Cells in Peripheral Blood of 49 Cases with Nasopharyngeal Carcinoma |
| 投稿时间：2018-08-26 |
| DOI：10.11735/j.issn.1671-170X.2019.02.B005 |
|
 |
| 中文关键词: 循环肿瘤细胞 鼻咽肿瘤 CanPatrolTM |
| 英文关键词:circulating tumor cells nasopharyngeal carcinoma CanPatrolTM |
| 基金项目:浙江省医药卫生科技计划A类项目(2016KYA157) |
|
| 摘要点击次数: 2623 |
| 全文下载次数: 514 |
| 中文摘要: |
| 摘 要：［目的］ 分析外周血循环肿瘤细胞在鼻咽癌中的表达及其临床意义。［方法］ 采用CanPatrolTM循环肿瘤细胞分型检测技术检测循环肿瘤细胞在49例初治鼻咽癌和20例正常人中的表达情况，分析循环肿瘤细胞的表达与分期和EB病毒的关系。［结果］ 鼻咽癌患者中循环肿瘤细胞阳性率为57.1%，而正常人阳性率为 0，差异有统计学意义（χ2=16.991，P＜0.05）。M0期和M1期患者中，循环肿瘤细胞阳性率分别为 48.8% 和 87.5%，差异有统计学意义（χ2=6.853，P=0.008）；EBV-DNA 阴性和阳性患者中，阳性率分别为39.4%和88.2%，差异有统计学意义（χ2=6.983，P=0.013）。［结论］ 循环肿瘤细胞与鼻咽癌有无全身转移和EBV-DNA密切相关，可用于鼻咽癌病情的评估。 |
| 英文摘要: |
| Abstract：［Objective］ To analyze the expression of circulating tumor cells (CTCs) in patients with nasopharyngeal carcinoma(NPC) and its clinical significance. ［Methods］ The expression of CTCs in 49 non-treated NPC patients and 20 healthy persons was detected by CanPatrolTM CTC detection technology. The relationship of CTCs expression with stage and EB virus were analyzed.［Results］ The positive rate of CTCs in NPC patients and healthy person was 57.1% and 0 respectively(χ2=16.991，P＜0.05).The positive rate in M0 and M1 NPC patients was 48.8% and 87.5% respectively(χ2=6.853，P=0.008). The positive rate in NPC patients with negative EBV-DNA and positive EBV-DNA was 39.4% and 88.2%(χ2=6.983，P=0.013).［Conclusion］ CTCs are closely related to systemic metastasis and EBV-DNA of nasopharyngeal carcinoma，it can be used to evaluate the condition of nasopharyngeal carcinoma. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |