| 韩 雪,林 杉,赵子伟.血浆钙离子、25-羟基维生素D、CaSR及E-cadherin在乳腺癌中的表达及意义[J].肿瘤学杂志,2019,25(1):47-50. |
| 血浆钙离子、25-羟基维生素D、CaSR及E-cadherin在乳腺癌中的表达及意义 |
| Expressions of Plasma Calcium Ions，25-Hydroxyvitamin D，CaSR and E-Cadherin in Breast Cancer and Clinical Significance |
| 投稿时间：2018-02-28 |
| DOI：10.11735/j.issn.1671-170X.2019.01.B011 |
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| 中文关键词: 乳腺癌 血浆钙离子 25-羟基维生素D CaSR E-cadherin |
| 英文关键词:breast cancer plasma calcium ion 25-hydroxyl vitamin D CaSR E-cadherin |
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| 中文摘要: |
| 摘 要：［目的］ 探讨血浆钙离子、25-羟基维生素D、组织中钙敏感受体（calcium sensitive receptor，CaSR）及E-钙黏蛋白（E-calciummucin，E-cadherin）在乳腺癌患者中表达水平及临床意义。［方法］ 研究对象为2015年2月至2017年2月经手术切除治疗的乳腺癌患者360例（A组）、同期100例乳腺良性肿块患者（B组）和40例乳腺癌旁组织标本（距癌灶边缘5cm）（C组）。入院确诊后未经治疗前，采用离子选择电极法检测A组、B组血钙离子水平，采用酶联免疫吸附法（ELISA）检测A组、B组25-羟基维生素D水平；三组均实施E-cadherin及CaSR免疫组化。［结果］ A组血浆钙离子与25-羟基维生素D水平均低于B组（P<0.05）；A组CaSR阳性率高于B组、C组（P<0.05）；A组E-cadherin阳性率低于B组、C组（P<0.05）；乳腺癌E-cadherin、CaSR、血钙、25-羟基维生素D表达与TNM分期、病理类型之间无统计学意义（P>0.05），但与淋巴结转移之间有统计学意义（P<0.05）。［结论］ 血浆钙离子、25-羟基维生素D、CaSR及E-cadherin与乳腺癌病变密切相关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of plasma calcium ions，25-hydroxyvitamin D ［25(OH) D］，calcium sensitive receptors(CaSR) and E-cadherin in breast cancer patients and their clinical significance. ［Method］ Three hundred and sixty patients with breast cancer receiving surgical resection in our hospital from February 2015 to February 2017(group A)，100 patients with benign breast masses(group B) were enrolled in the study. Forty specimens of pericancerous tissue were collected from breast cancer patients were also collected(group C). The serum calcium ion levels were measured with by electrode method，25(OH)D levels were determined by enzyme-linked immunosorbent assay(ELISA)，the expression of E-cadherin and CaSR was detected by immunohistochemistry. ［Results］ The average plasma calcium ion and 25(OH)D levels in group A were lower than those in group B(P<0.05). The positive rate of CaSR in group A was higher than that in group B and group C(P<0.05). The positive rate of E-cadherin in group A was lower than that in group B and group C(P<0.05). The expression of E-cadherin，CaSR，blood calcium and 25(OH)D was not correlated with TNM stage and pathological type(P>0.05)，but correlated with lymph node metastasis(P<0.05). ［Conclusion］ Plasma calcium，25-hydroxyvitamin D，CaSR and E-cadherin are associated with breast cancer. |
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