| 焦得闯,乔江华,朱久俊.前哨淋巴结阳性早期乳腺癌患者非前哨淋巴结阳性预测因素[J].肿瘤学杂志,2019,25(1):32-35. |
| 前哨淋巴结阳性早期乳腺癌患者非前哨淋巴结阳性预测因素 |
| Predictive Factors Related to Metastasis of Non-sentinel Lymph Nodes in Early Breast Cancer Patients with Positive Sentinel Lymph Nodes |
| 投稿时间：2018-03-16 |
| DOI：10.11735/j.issn.1671-170X.2019.01.B008 |
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| 中文关键词: 乳腺癌 非前哨淋巴结 预测因素 |
| 英文关键词:breast cancer non-sentinel lymph nodes predictive factor |
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| 中文摘要: |
| 摘 要：［目的］ 探讨前哨淋巴结( sentinel lymph node，SLN)阳性早期乳腺癌患者非前哨淋巴结转移的预测因素。［方法］ 回顾性分析2010年7月至2017年8月河南省肿瘤医院578例SLN阳性乳腺癌患者的临床病例资料。通过术中印片及术后连续切片HE染色检测SLN。［结果］ 全组女性非前哨淋巴结阳性率为38.4%。单因素分析显示，阳性SLN数目（χ2=70.114，P=0.001）、阴性SLN数目（χ2=49.095，P<0.001）及Ki67表达水平（χ2=6.924，P=0.009）与非前哨淋巴结转移相关。多因素分析显示，阳性SLN数目(OR=2.076，95％CI：1.686~2.556，P<0.001)、阴性SLN数目(OR=0.673，95％CI：0.586~0.773，P<0.001)和Ki67表达水平(OR=1.807，95％CI：1.150~2.840，P=0.010)是非前哨淋巴结转移的独立预测因素。［结论］ 阳性SLN数目、阴性SLN数目和Ki67表达是乳腺癌非前哨淋巴结转移的独立预测因素。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the predictive factors related to the metastasis of non-sentinel lymph nodes(NSLN) in early breast cancer patients with positive sentinel lymph nodes (SLN)．［Methods］ The clinical data of 578 female breast cancer patients with positive SLN admitted in Henan Tumor Hospital from July 2010 to August 2017 were analyzed retrospectively. Touch imprint cytology and serial sectioning with H&E staining were routinely performed on each sentinel node. The factors related to the metastases of NSLN were analyzed with univariate and multivariate Logistic regression analysis. ［Results］ Positive NSLN were found in 38.4％ of 578 patients．Univariate analysis showed that the number of positive SLN（χ2=70.114，P<0.001），the number of negative SLN（χ2=49.095， P<0.001），and expression level of Ki67（χ2=6.924，P=0.009） were associated with NSLN metastasis. Multivariate analysis showed that the number of positive SLN(OR=2.076，95％CI：1.686~2.556，P<0.001)，the number of negative SLN(OR=0.673，95％CI：0.586~0.773，P<0.001)，and the expression level of Ki67(OR=1.807，95％CI：1.150~2.840，P=0.010) were independent predictors of NSLN metastasis. ［Conclusion］ Number of positive SLN，number of negative SLN and the expression level of Ki67 are predictive factors of NSLN metastasis in breast cancer patients with positive SLN. |
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