| 臧传鑫,刘瑞娟,赵文歌.乳腺癌干细胞相关信号通路及其抑制剂的研究进展[J].肿瘤学杂志,2019,25(1):27-31. |
| 乳腺癌干细胞相关信号通路及其抑制剂的研究进展 |
| Research Progress of Breast Cancer Stem Cell Related Signal Pathway and Its Inhibitor |
| 投稿时间：2017-07-17 |
| DOI：10.11735/j.issn.1671-170X.2019.01.B007 |
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| 中文关键词: 乳腺癌 乳腺癌干细胞 信号通路 抑制剂 |
| 英文关键词:breast cancer breast cancer stem cell signal pathway inhibitor |
| 基金项目:国家自然科学基金资助项目(81473513；81673799；81273987)；淮坊市科技发展计划项目（2016YX045） |
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| 中文摘要: |
| 摘 要：乳腺癌干细胞是乳腺癌组织中少数具备自我更新能力与多向分化潜能的细胞，与乳腺癌的发生发展密切相关。目前，乳腺癌治疗后易转移、易复发与乳腺癌干细胞的存在相关。乳腺癌干细胞信号通路在激活乳腺癌细胞功能、乳腺癌调控细胞分化以及控制乳腺癌细胞分裂方面起着关键作用，打破其平衡状态将导致乳腺癌细胞失控性增长及肿瘤发生。针对相应通路进行阻断性靶向治疗可能成为乳腺癌治疗的新视角。全文主要就乳腺癌干细胞相关信号通路及其抑制剂的研究进展进行阐述，以期为乳腺癌患者获得更加有效的临床治疗提供参考。 |
| 英文摘要: |
| Abstract：Breast cancer stem cells are a few cells with self-renewal capacity and multi-directional differentiation in breast cancer tissue，which are closely related to the occurrence and development of breast cancer. At present，the clinical treatment of breast cancer is easy to metastasis and recurrence is related to the existence of breast cancer stem cells. Therefore，it is necessary to seek the treatment of breast cancer stem cells. And breast cancer stem cell signaling pathway plays a key role in the activation of breast cancer cell function，breast cancer cell differentiation and control of breast cancer cell division，breaking its balance status will lead to breast cancer cell growth and cancer. Therefore，targeted therapy for the corresponding pathway may become a new perspective of breast cancer treatment. This paper mainly expounds the research progress of hedgehog signaling pathway and its inhibitors，in order to provide reference for more effective clinical treatment for breast cancer patients. |
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