李 伟,李文杰,钱 诚.循环肿瘤DNA在三阴性乳腺癌中的检测及其潜在应用价值[J].肿瘤学杂志,2019,25(1):7-11.
循环肿瘤DNA在三阴性乳腺癌中的检测及其潜在应用价值
Detection and Potential Value of Circulating Tumor DNA in Triple-Negative Breast Cancer
投稿时间:2017-08-03  
DOI:10.11735/j.issn.1671-170X.2019.01.B003
中文关键词:  循环肿瘤DNA  三阴性乳腺癌  潜在应用价值
英文关键词:circulating tumor DNA  triple-negative breast cancer  potential value
基金项目:
作者单位
李 伟 哈尔滨医科大学附属肿瘤医院 
李文杰 哈尔滨医科大学附属肿瘤医院 
钱 诚 哈尔滨医科大学附属肿瘤医院 
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中文摘要:
      摘 要:三阴性乳腺癌(TNBC)是一种复发率高、总生存率低的高侵袭性疾病。TNBC具有高度异质性,且雌激素受体(ER)、孕激素受体(PR)及人类表皮生长因子受体2(Her-2)均为阴性,决定了其临床预后较差。循环肿瘤DNA(ctDNA)作为新型生物标志物,不仅可以监测TNBC的新辅助疗效与微小残留病灶,而且有助于早期发现转移性疾病,进而指导TNBC的个体化治疗,改善其临床预后。全文就ctDNA检测技术作一介绍,并重点阐述ctDNA在TNBC中的潜在应用价值。
英文摘要:
      Abstract:Triple-negative breast cancer(TNBC) is a highly invasive disease with high recurrence rate and low overall survival rate. TNBC has high heterogeneity, and estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor 2(Her-2) are all negative, which determine the poor clinical prognosis. Circulating tumor DNA(ctDNA) as a new biological marker, not only can indicate neoadjuvant curative effect and minimal residual disease, but can detect the early metastatic disease, which guides TNBC individualized treatment, and improves the clinical prognosis. This review briefly shows the detection technology of ctDNA, and highlights the potential value of ctDNA in TNBC.
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