| 邵长春,郝森森,吴高淇.环状RNA在乳腺癌中的研究进展[J].肿瘤学杂志,2018,24(11):1112-1117. |
| 环状RNA在乳腺癌中的研究进展 |
| Research Progress and Prospect of Circular RNA in Breast Cancer |
| 投稿时间：2018-06-07 |
| DOI：10.11735/j.issn.1671-170X.2018.11.B016 |
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| 中文关键词: 环状RNA 乳腺癌 标志物 研究进展 |
| 英文关键词:circularRNA breast cancer biomaker progress |
| 基金项目:广东省公益研究与能力建设专项基金(2014A020210026)；广东省自然科学基金研究团队项目(2016A030312008)；国家自然科学基金国际合作(81320108015) |
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| 中文摘要: |
| 摘 要： 环状RNA(circularRNA，circRNA)是一类不同于线性RNA的新型RNA，其5′与3′端首尾相连形成共价闭合的单链环状分子。通常由基因外显子、内含子、或者两者共同组成，并且广泛存在于多种生物体中，进化上具有保守性、相对稳定、不易被核酸外切酶降解，具有组织特异性以及发展阶段特异性，在正常生理活动以及各种疾病进程中具有重要的作用，是一个潜在的疾病诊断、预后标志物，以及治疗靶点。全文主要论述环状RNA特性、作用机制、研究方法、在乳腺癌中的研究进展、潜在临床价值以及问题展望等。 |
| 英文摘要: |
| Abstract：Circular RNA(circRNA) is a novel type of RNA which is different from linear RNA. CircRNAs are the single-stranded circular molecules with a covalently closed loop structure that lack 5’- 3’polarity or a polyadenylated tail. They are composed of gene exons，introns，or both，and are widely expressed in a variety of organisms. They are well conserved in sequence，relatively stable，and not easily degraded by exonucleolytic enzymes. More importantly，circRNAs have tissue specificity and developmental stage specificity，and play an important role in normal physiological activities and various disease process，indicating that circRNA are potential diagnosis and prognostic markers，and therapeutic targets for various diseases. This article mainly discusses the characteristics of circRNA，regulatory mechanism，research method，research progress，potential clinical value，and prospect of circRNA in breast cancer. |
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