张 媛,张 競,张庆松.L1-CAM在Ⅰ型子宫内膜癌中的表达及其临床意义[J].肿瘤学杂志,2018,24(11):1088-1091.
L1-CAM在Ⅰ型子宫内膜癌中的表达及其临床意义
Expression of L1-CAM in Endometrial Carcinoma and Its Clinical Significance
投稿时间:2018-07-02  
DOI:10.11735/j.issn.1671-170X.2018.11.B011
中文关键词:  L1细胞黏附分子  子宫内膜癌  临床病理因素  免疫组化
英文关键词:L1-cell adhesion molecule  endometrial carcinoma  clinicopathological factors  immunohistochemistry
基金项目:
作者单位
张 媛 蚌埠医学院第一附属医院 
张 競 蚌埠医学院第一附属医院 
张庆松 蚌埠医学院第一附属医院 
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中文摘要:
      摘 要:[目的] 探讨L1细胞黏附分子(L1-CAM)在子宫内膜癌组织中的表达及其与子宫内膜癌临床病理因素的关系。[方法] 应用免疫组化SP法检测90例子宫内膜癌和30例正常子宫内膜组织中L1-CAM的表达情况,分析其与子宫内膜癌各临床病理因素的关系。[结果] 子宫内膜癌组织中L1-CAM表达的阳性率为48.9%(44/90),显著性高于正常子宫内膜组织表达的阳性率(13.3%,4/30)(P<0.05)。L1-CAM阳性表达与子宫内膜癌细胞分化、肌层浸润深度、淋巴结转移有关(P均<0.05);与年龄因素、临床分期、肿瘤病灶大小无关(P>0.05)。[结论] L1-CAM的异常表达与子宫内膜癌的发生发展有关,检测L1-CAM有望作为早期诊断子宫内膜癌及评估预后的重要指标。
英文摘要:
      Abstract:[Objective] To investigate the expression of L1 cell adhesion molecule(L1-CAM) in endometrial carcinoma and its relationship with clinicopathological features. [Methods] Immunohistochemical SP method was used to detect the expression of L1-CAM in 90 samples of endometrial carcinoma and 30 samples of normal endometrium. The relationship between the expression of L1-CAM and the clinicopathological factors of endometrial carcinoma was analyzed.[Results] The positive rate of L1-CAM expression in endometrial carcinoma(48.9%,44/90) was significantly higher than that in normal endometrium(13.3%,4/30)(P<0.05).The abnormal expression of L1-CAM was correlated with the differentiation of endometrial carcinoma cells,depth of myometrial invasion and lymph node metastasis(all P<0.05),not correlated with age,clinical stage and tumor size of endometrial carcinoma(all P>0.05 ). [Conclusion] L1-CAM is over-expressed in endometrial carcinoma,and it is correlated with the clinicopathological features of the cancer.
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