| 张 媛,张 競,张庆松.L1-CAM在Ⅰ型子宫内膜癌中的表达及其临床意义[J].肿瘤学杂志,2018,24(11):1088-1091. |
| L1-CAM在Ⅰ型子宫内膜癌中的表达及其临床意义 |
| Expression of L1-CAM in Endometrial Carcinoma and Its Clinical Significance |
| 投稿时间：2018-07-02 |
| DOI：10.11735/j.issn.1671-170X.2018.11.B011 |
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| 中文关键词: L1细胞黏附分子 子宫内膜癌 临床病理因素 免疫组化 |
| 英文关键词:L1-cell adhesion molecule endometrial carcinoma clinicopathological factors immunohistochemistry |
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| 中文摘要: |
| 摘 要：［目的］ 探讨L1细胞黏附分子（L1-CAM）在子宫内膜癌组织中的表达及其与子宫内膜癌临床病理因素的关系。［方法］ 应用免疫组化SP法检测90例子宫内膜癌和30例正常子宫内膜组织中L1-CAM的表达情况，分析其与子宫内膜癌各临床病理因素的关系。［结果］ 子宫内膜癌组织中L1-CAM表达的阳性率为48.9%（44/90），显著性高于正常子宫内膜组织表达的阳性率（13.3%，4/30）（P＜0.05）。L1-CAM阳性表达与子宫内膜癌细胞分化、肌层浸润深度、淋巴结转移有关（P均＜0.05）；与年龄因素、临床分期、肿瘤病灶大小无关（P>0.05）。［结论］ L1-CAM的异常表达与子宫内膜癌的发生发展有关，检测L1-CAM有望作为早期诊断子宫内膜癌及评估预后的重要指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of L1 cell adhesion molecule(L1-CAM) in endometrial carcinoma and its relationship with clinicopathological features. ［Methods］ Immunohistochemical SP method was used to detect the expression of L1-CAM in 90 samples of endometrial carcinoma and 30 samples of normal endometrium. The relationship between the expression of L1-CAM and the clinicopathological factors of endometrial carcinoma was analyzed.［Results］ The positive rate of L1-CAM expression in endometrial carcinoma(48.9%，44/90） was significantly higher than that in normal endometrium(13.3%，4/30）(P<0.05).The abnormal expression of L1-CAM was correlated with the differentiation of endometrial carcinoma cells，depth of myometrial invasion and lymph node metastasis(all P<0.05)，not correlated with age，clinical stage and tumor size of endometrial carcinoma(all P>0.05 ). ［Conclusion］ L1-CAM is over-expressed in endometrial carcinoma，and it is correlated with the clinicopathological features of the cancer. |
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