| 李营歌,姚 颐,宋启斌.肿瘤免疫治疗不容忽视的微环境：癌相关成纤维细胞[J].肿瘤学杂志,2018,24(11):1060-1064. |
| 肿瘤免疫治疗不容忽视的微环境：癌相关成纤维细胞 |
| Microenvironment That Tumor Immunotherapy Cannot Ignore：Cancer-associated Fibroblasts |
| 投稿时间：2018-04-11 |
| DOI：10.11735/j.issn.1671-170X.2018.11.B005 |
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| 中文关键词: 癌相关成纤维细胞 肿瘤免疫 免疫治疗 靶向治疗 |
| 英文关键词:cancer associated fibroblasts tumor immune immunotherapy targeted therapy |
| 基金项目:国家自然科学基金（81670123） |
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| 摘要点击次数: 2059 |
| 全文下载次数: 570 |
| 中文摘要: |
| 摘 要：癌相关成纤维细胞（cancer associated fibroblasts，CAF），肿瘤微环境中宿主细胞主要成分，除具有直接促瘤作用外，还可通过抑制T细胞功能、促进免疫抑制细胞功能、调节胞外基质结构参与肿瘤免疫抑制微环境的形成。抑制CAF功能和以CAF为靶点的抗肿瘤微环境治疗为免疫治疗提供新的辅助手段。 |
| 英文摘要: |
| Abstract：Cancer associated fibroblasts (CAF)，the main components of the host cells in the tumor microenvironment，not only have a direct “tumor promoting” role，but also participate in the formation of immunosuppressive microenvironment by inhibiting T lymphocyte function，promoting immunosuppressive cell function，and regulating the structure of extracellular matrix. Anti-tumor microenvironment therapy that inhibits CAF function would provide a new auxiliary method for immunotherapy. |
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