| 张晓飞,魏亚强.抗癌平丸联合调强适形放疗对老年腹腔镜超低位直肠癌根治术后复发的临床疗效观察[J].肿瘤学杂志,2018,24(10):992-996. |
| 抗癌平丸联合调强适形放疗对老年腹腔镜超低位直肠癌根治术后复发的临床疗效观察 |
| Kang′aiping Pills Combined with Intensity Modulated Radiation in Treatment of Recurrence for Elderly Patients with Ultra?鄄low Rectal Cancer after Laparoscopic Radical Resection |
| 投稿时间：2017-08-04 |
| DOI：10.11735/j.issn.1671-170X.2018.10.B011 |
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| 中文关键词: 抗癌平丸 调强适形放射 老年 腹腔镜超低位直肠癌根治术 复发 |
| 英文关键词:Kang′aiping pills intensity modulated radiation elderly laparoscopic radical resection for ultralow rectal cancer recurrence |
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| 中文摘要: |
| 摘 要：［目的］探讨抗癌平丸联合调强适形放射治疗老年腹腔镜超低位直肠癌根治术后复发的临床疗效。［方法］ 将收治的82例老年腹腔镜超低位直肠癌根治术后复发患者作为研究对象，随机分为观察组和对照组，每组41例。对照组采用调强适形放射治疗，观察组在对照组治疗基础上同时给予抗癌平丸口服。治疗6周后，观察两组组临床获益率（CBR）及客观缓解率（ORR）。治疗前后，分别检测两组患者免疫球蛋白（IgM、IgG及IgA）及T细胞亚群（CD3+、CD4+）水平。治疗期间观察两组组患者各项不良反应。［结果］ 治疗后，观察组CBR和ORR分别为92.7%和82.9%，均分别高于对照组的78.0%和68.2%（P<0.05）。治疗后，观察组IgM、IgG、IgA、CD3+及CD4+水平分别均分别高于对照组（P<0.05）。治疗期间，观察组各项不良反应的发生率均明显低于对照组（P<0.05）。［结论］ 抗癌平丸联合调强适形放射治疗老年腹腔镜超低位直肠癌根治术后复发疗效较好，且能够有效降低患者不良反应，提高患者免疫功能。 |
| 英文摘要: |
| Abstract：［Objective］ To assess the efficacy of Kang′aiping pills combined with intensity modulated radiation in treatment of recurrence in elderly patients with ultra-low rectal cancer after laparoscopic radical resection. ［Methods］ Eighty-two elderly patients with ultra-low rectal cancer received laparoscopic radical resection，local recurrence occurred following surgery. Patients were randomly divided into two study group and control group with 41 cases in each group. All patients underwent intensity modulated radiation for 6 weeks，patients in study group received additional administration of Kang′aiping pills. The clinical benefit rate and objective response rate were evaluated in two groups. The levels of IgM，IgG，IgA，CD3+ and CD4+ were detected before and after the treatment. The adverse reactions were compared between two groups. ［Results］ The clinical benefit rate and objective response rate were 92.7% and 82.9% in the study group，which were significantly higher than those in the control group(78.0% and 68.2%)(P<0.05). After the treatment，the levels of IgM，IgG，IgA，CD3+ and CD4+ in study group were significantly higher than those in control group(all P<0.05). During the treatment，there were no serious toxicity in two groups and the incidence of adverse reactions in study group was significantly lower than that in control group(all P<0.05). ［Conclusion］ Kang′aiping pills combined with intensity modulated radiation is effective and safe with the increased immunity in treatment of recurrence for elderly patients with ultralow rectal cancer after laparoscopic radical resection. |
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