| 徐绮腻,王鸿彪.食管鳞癌组织中CENP-F蛋白表达及临床意义[J].肿瘤学杂志,2018,24(10):977-980. |
| 食管鳞癌组织中CENP-F蛋白表达及临床意义 |
| Expression of CENP-F in Esophageal Squamous Cell Carcinoma and Its Clinical Significance |
| 投稿时间：2017-07-21 |
| DOI：10.11735/j.issn.1671-170X.2018.10.B008 |
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| 中文关键词: CENP-F 食管肿瘤 预后 |
| 英文关键词:CENP-F esophageal neoplasm prognosis |
| 基金项目: |
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| 摘要点击次数: 2355 |
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| 中文摘要: |
| 摘 要：［目的］ 探索CENP-F在食管鳞癌中的表达，分析其与食管鳞癌临床病理参数及预后的关系。［方法］ 采用免疫组织化学法检测CENP-F在186例食管鳞癌组织标本及癌旁正常组织的表达水平，分析CENP-F表达与临床病理参数的关系，Kaplan-Meier法比较生存时间，Cox回归模型进行预后分析。［结果］ CENP-F在食管鳞癌组织和癌旁正常组织的阳性表达率分别为48.4%（90/186）和0.54% (1/186)（χ2=115.23，P<0.01）。CENP-F表达水平与T分期（χ2=7.69，P<0.01）、病理分期（χ2=6.24，P<0.01）有关；与年龄（χ2=2.93，P=0.08）、性别（χ2=0.008，P=0.93）、淋巴结转移（χ2=1.34，P=2.24）、分化程度（χ2=1.37，P=0.50）无关。CENP-F表达阳性和阴性患者的中位生存时间分别为39个月和14个月（χ2=57.57，P<0.01）。单因素和多因素分析均显示CENP-F蛋白是不良预后因素。［结论］ CENP-F蛋白在食管鳞癌组织高表达，且提示不良预后。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression and clinical implication of CENP-F in esophageal squamous cell carcinoma. ［Methods］ One-hundred and eighty six esophageal squamous cell carcinoma tissues and adjacent non-cancerous tissues were collected，and the expression of CENP-F was detected by immunohistochemistry. The relation between CENP-F and clinical pathological characteristics was analyzed. The overall survival was calculated by the Kaplan-Meier method. Multivariate analysis to determine independent prognostic factors was performed by the Cox regression model. ［Results］ Positive expression rates of CENP-F were 48.4%(90/186) and 0.54%(1/186) in primary tumors and their matched adjacent non-cancerous tissues，respectively(χ2=115.23，P<0.01). Significant differences in CENP-F expression were found between T stage(χ2=7.69，P<0.01) and pathological stage(χ2=6.24，P<0.01). No significant differences in CENP-F expression were found among other clinicopathologic features，including age(χ2=2.93，P=0.08)，gender(χ2=0.008，P=0.93)，lymph node metastasis(χ2=1.34，P=2.24) and differentiation(χ2=1.37，P=0.50). The median overall survival time for CENP-positive and negative were 14 months and 39 months，respectively(χ2=57.57，P<0.01). Univariate and multivariate analysis both demonstrated CENP-F as an unfavorable prognostic factor. ［Conclusion］ The expression of CENP-F in esophageal squamous cell carcinoma is high and indicated poor prognosis. |
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