张艳霞,孙婉玲.CAR-T在多发性骨髓瘤治疗中的研究进展[J].肿瘤学杂志,2018,24(10):957-960.
CAR-T在多发性骨髓瘤治疗中的研究进展
Research Progress of CAR-T Therapy in Multiple Myeloma
投稿时间:2018-07-08  
DOI:10.11735/j.issn.1671-170X.2018.10.B004
中文关键词:  CAR-T  多发性骨髓瘤  B细胞成熟抗原  细胞因子释放综合症
英文关键词:chimeric antigen receptors  multiple myeloma  B cell maturation antigen  cytokine release syndrome
基金项目:
作者单位
张艳霞 首都医科大学宣武医院 
孙婉玲 首都医科大学宣武医院 
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中文摘要:
      摘 要:多发性骨髓瘤(MM)是一种以骨髓中单克隆浆细胞大量增生为特征的、近乎无法治愈的血液系统恶性疾病。近十余年来,随着新药的不断涌现,MM的治疗取得了重大进展,但复发/难治性MM患者的治疗仍面临巨大挑战。近年来,CAR-T细胞疗法迅速发展,最先用于B细胞恶性肿瘤,并取得优异的成果。关于CAR-T治疗MM的研究也逐渐增多,CAR-T治疗MM虽处于早期发展阶段,但潜力无穷。全文重点介绍了CAR-T治疗MM的研究进展。
英文摘要:
      Abstract:Multiple myeloma(MM) is a nearly incurable hematologic malignancy,with proliferating of monoclonal plasma cells in the bone marrow. Despite considerable new drugs and the improvement in treatment response over the past decade,outcome of relapsed/refractory MM remains a great challenge. CAR-T(chimeric antigen receptor-T cell) therapy has developed rapidly in recent years,which was first used in B cell tumors,and has achieved encouraging results. Researches on CAR-T therapy for MM are gradually increasing,and CAR-T therapy for MM is still at the early stage,it may bring promising result in the future. The progress of CAR-T therapy in multiple myeloma is discussed in this article.
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