王 岩,王林月,黄仲夏.激活素A在多发性骨髓瘤发病中的研究进展[J].肿瘤学杂志,2018,24(10):948-951. |
激活素A在多发性骨髓瘤发病中的研究进展 |
Research Progress of Activin A in Pathogenesis of Multiple Myeloma |
投稿时间:2018-07-09 |
DOI:10.11735/j.issn.1671-170X.2018.10.B002 |
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中文关键词: 激活素A 多发性骨髓瘤 骨病 贫血 |
英文关键词:activin A multiple myeloma bone disease anemia |
基金项目:北京市石景山区重点扶持专科建设项目(20170006) |
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中文摘要: |
摘 要:多发性骨髓瘤(MM)是恶性浆细胞肿瘤,引起血钙升高、肾损害贫血和骨损害(CRAB症状,症状性骨髓瘤)。在MM患者中,高水平的激活素A不仅与MM的病情进展有关,与MM的溶骨性骨质破坏、贫血也相关,且影响MM患者的预后。抗激活素A疗法的应用,不仅可治疗MM相关的骨质破坏、贫血,也能改善MM患者的预后,故激活素A可能是MM或肿瘤性骨病的有希望的治疗靶点,特别是合并肿瘤性贫血的患者 |
英文摘要: |
Abstract:Multiple myeloma(MM) is a malignant plasma cell tumor that causes elevated blood calcium,anemia,kidney damage,and bone destruction(CRAB symptoms,symptomatic myeloma). In MM patients,high levels of activin A are not only related to the progression of MM,but also related to osteolytic bone destruction and anemia,affecting the prognosis of MM patients. The application of anti-activin A therapy can treat MM-related bone destruction and anemia,and improve the survival of MM patients,so activin A may be a promising therapeutic target for MM or tumor-induced bone disease,especially for patients with tumor-related anemia.。 |
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