| 高海燕,代建波,薛 娇.纳米碳混悬液联合亚甲蓝注射液在早期乳腺癌前哨淋巴结活检中示踪效果对比分析[J].肿瘤学杂志,2018,24(9):892-895. |
| 纳米碳混悬液联合亚甲蓝注射液在早期乳腺癌前哨淋巴结活检中示踪效果对比分析 |
| Carbon Nanoparticle Suspension with Methylene Blue Injection in Sentinel Lymph Node Biopsy for Early Breast Cancer Patients |
| 投稿时间：2018-06-11 |
| DOI：10.11735/j.issn.1671-170X.2018.09.B010 |
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| 中文关键词: 乳腺癌 纳米碳 亚甲蓝 前哨淋巴结活检术 |
| 英文关键词:breast cancer nanocarbon methylene blue sentinel lymph node biopsy |
| 基金项目:南京医科大学科技发展基金重点项目（2016NJMUZD082） |
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| 摘要点击次数: 1915 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨纳米碳混悬液联合亚甲蓝注射液在早期乳腺癌前哨淋巴结活检（SLNB）中示踪效果。［方法］ 2017年5月至2018年5月收治T1～T2N0M0期180例女性乳腺癌患者，按随机数字表达法分为3组，A组为纳米碳组，B组为亚甲蓝组，C组为纳米碳联合亚甲蓝组，每组60例。A组采用纳米碳混悬液为示踪剂，B组采用亚甲蓝注射液为示踪剂，C组采用常规一半剂量的纳米碳混悬液联合亚甲蓝注射液为示踪剂。术后比较三组患者的前哨淋巴结检出率、准确率、敏感度、假阴性率，以及术中寻找前哨淋巴结所需的时间和淋巴结检出数。［结果］ A组前哨淋巴结检出率为96.67%，敏感度为92.31%，准确率为93.33%，假阴性率为7.69%；B组前哨淋巴结检出率为93.33%，敏感度为91.30%，准确率为90.00%，假阴性率为8.69%；C组前哨淋巴结检出率为98.33%，敏感度为93.10%，准确率为95.00%，假阴性率为6.89%，三组比较差异无统计学意义(P＞0.05)。A组术中寻找前哨淋巴结时间为(23.32±5.49)min，淋巴结检出数(3.28±1.11) 枚；B组为(25.54±3.68)min，淋巴结检出数(2.36±0.79) 枚；C组为(21.53±4.92)min，淋巴结检出数(4.19±1.10) 枚，三组前哨淋巴结时间及淋巴结检出数比较差异有统计学意义(P＜0.05)。［结论］ 纳米碳混悬液与亚甲蓝注射液两种示踪剂应用于早期乳腺癌SLNB中，均具有较好的检出率，但联合组寻找前哨淋巴结所花时间更短，淋巴结检出数量更多，且未见副作用，值得临床推广与应用。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the application of nanocarbon suspension combined with methylene blue injection in sentinel lymph node biopsy（SLNB） for patients with early breast cancer. ［Methods］ One hundred and eighty female breast cancer patients diagnosed as T1～T2N0M0 in our hospital from May 2017 to May 2018 were randomly divided into three groups with 60 cases in each group. In group A，nano-carbon suspension was used as a tracer，group B was traced with methylene blue injection，and group C was traced with nano-carbon suspension combined and methylene blue injection. The sentinel lymph node detection rate，diagnostic accuracy，sensitivity，false negative rate and the time spent for finding the sentinel lymph nodes during surgery，the number of lymph node detected were compared in three groups. ［Results］ The detection rate of sentinel lymph nodes in group A，B and C was 96.67%，93.33% and 98.33%，the sensitivity of three groups was 92.31%，91.30% and 93.10%，the accuracy rate was 93.33%，90.00% and 95.00%，the false negative rate was 7.69%，8.69% and 6.89%，respectively. There was no significant difference among the three groups (P>0.05). The tracing time for sentinel lymph node in group A，B and C was(23.32±5.49)min，(25.54±3.68)min and (21.53±4.92)min，the number of detected lymph nodes in three groups was 3.28±1.11，2.36±0.79 and 4.19±1.10，respectively (all P<0.05). ［Conclusion］ Nanocarbon suspension and methylene blue injection both are effective in tracing SLNB for early breast cancer，however，the combination of two techniques may detect more sentinel lymph nodes and take less time. |
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