| 周 磊,胡广原,席青松.米诺环素用于食管癌同步放化疗导致的中重度乏力的临床观察[J].肿瘤学杂志,2018,24(9):870-874. |
| 米诺环素用于食管癌同步放化疗导致的中重度乏力的临床观察 |
| Effect and Safety of Minocycline for Moderate and Severe Fatigue During Concurrent Chemoradiotherapy in Patients with Esophageal Cancer |
| 投稿时间：2018-02-08 |
| DOI：10.11735/j.issn.1671-170X.2018.09.B005 |
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| 中文关键词: 食管癌 同步放化疗 乏力 米诺环素 |
| 英文关键词:esophageal cancer concurrent chemoradiotherapy fatigue minocycline |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 评价同步放化疗中出现中重度癌症相关性乏力的食管鳞癌患者使用米诺环素能否改善其乏力程度以及评估用药的安全性。［方法］ ⅡB~ⅢC期食管鳞状细胞癌患者在同步放化疗期间每周一次晨起使用数字评分法评估其乏力程度，如患者乏力程度达到中重度开始给予米诺环素100mg，口服，每日2次，直至同步放化疗结束。采用开放型双向序贯t检验方法比较口服米诺环素治疗2周后晨起乏力程度，并观察治疗安全性。［结果］ 共入组12例，服用米诺环素后，乏力未改善4例(33.3%)，改善8例(66.7%)。由于试验线触及上界U，且有∑di=12>0，可以认为米诺环素能够显著性改善患者的乏力程度。研究期间，未发现患者出现菌群失调、过敏、明显消化道反应及明显肝肾毒性。［结论］食管鳞癌患者在同步放化疗期间出现中重度乏力使用米诺环素能够改善患者的乏力程度，且治疗安全。 |
| 英文摘要: |
| bstract：［ Objective ］ To evaluate the efficacy and safety of minocycline for moderate or severe cancer-related fatigue in patients with esophageal squamous cell carcinoma during concurrent chemoradiatherapy. ［Methods］ Patients with stage IIB~IIIC esophageal squamous cell carcinoma were assessed for their degree of fatigue by using the digital scoring method once a week during concurrent chemoradiatherapy. Patients with moderate or severe fatigue were given 100mg minocycline q.d orally until the therapy was completed. The efficacy and safety of medication were assessed. ［Results］ Among 12 cases receiving minocycline the degree of fatigue was significantly improved in 8 cases，and not improved in 4 cases. Because the test line touched the upper bound U，and Σdi = 12> 0，minocycline was considered to significantly improve the patient’s degree of fatigue. During the study，no adverse reactions，including flora imbalance，allergy，significant gastrointestinal reaction，liver and kidney toxicity were observed. ［Conclusion ］ Administration of minocycline can significantly improve the degree of fatigue in patients with esophageal squamous cell carcinoma during concurrent chemoradiotherapy and the treatment is safe. |
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