| 王婵娟,朱 熹.EMT介导膀胱癌耐药的机制及相关分子[J].肿瘤学杂志,2018,24(8):813-817. |
| EMT介导膀胱癌耐药的机制及相关分子 |
| Mechanisms and Related Molecules of EMT-induced Chemoresistancein Bladder Cancer |
| 投稿时间：2017-06-06 |
| DOI：10.11735/j.issn.1671-170X.2018.08.B012 |
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| 中文关键词: 膀胱肿瘤 上皮-间充质转化 化疗耐药 信号分子 |
| 英文关键词:urinary bladder neoplasms epithelial-mesenchymal transition chemoresistance signaling molecules |
| 基金项目:国家自然科学基金资助项目（61401290）；北京市医院管理局青年人才培养“青苗”计划（QML20160104） |
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| 中文摘要: |
| 摘 要：化疗是治疗膀胱癌的重要手段，但是随着化疗的进行，肿瘤细胞往往对单药或多药化疗产生耐药，严重影响患者的预后。近年来研究表明，膀胱癌耐药性的产生受肿瘤微环境中多种信号分子的调节，上皮-间充质转化 (epithelial-mesenchymal transition，EMT)在其中发挥着关键性作用，多种分子通过不同的信号通路参与到EMT介导的膀胱癌耐药机制中。全文就EMT相关耐药机制进行探讨，旨在为EMT介导的耐药膀胱癌患者寻找新的治疗策略。 |
| 英文摘要: |
| Abstract：Chemotherapy plays an important role in the treatment of bladder cancer. However，the use of chemotherapeuticsmore than often leads to development of resistance in cancer cells to single- or multi-drug therapy，which seriously affects the prognosis of patients.Recent studies show that chemoresistance is regulated by varioustypes of signaling molecules in the tumor microenvironment，and that epithelial-mesenchymal transition(EMT) plays a crucial part in this process. Different types of molecules can participate in EMT-induced chemoresistance via different signaling pathways. In this review，the mechanisms of EMT-relatedchemoresistancewere identified in attempt to formulate new therapeutic strategies for bladder cancer patients who have developed chemoresistance. |
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