| 余志娟,汪 雷.LCN2在喉鳞状细胞癌淋巴结转移中的表达及意义[J].肿瘤学杂志,2018,24(8):783-786. |
| LCN2在喉鳞状细胞癌淋巴结转移中的表达及意义 |
| Expression of LCN2 in Lymph Node Metastasis of Laryngeal Squamous Cell Carcinoma and Its Significance |
| 投稿时间：2017-01-06 |
| DOI：10.11735/j.issn.1671-170X.2018.08.B006 |
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| 中文关键词: LCN2 喉鳞状细胞癌，淋巴结转移 |
| 英文关键词:LCN2 laryngeal squamous cell carcinoma lymph node metastasis |
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| 中文摘要: |
| 摘 要：［目的］ 分析LCN2在喉鳞状细胞癌淋巴结转移表达及意义。［方法］ 收集咸宁市中心医院耳鼻咽喉科56例喉鳞状细胞癌患者标本，免疫组化方法分析淋巴结转移组和非转移组原发灶及淋巴结中LCN2的表达；组织芯片分析LCN2与分化程度的相关性。［结果］ LCN2蛋白在转移组喉鳞状细胞癌原发灶和淋巴结中的表达明显高于非转移组（P<0.05）。LCN2蛋白在高分化喉癌中呈低表达，在低分化喉癌中呈高表达，分化程度与LCN2蛋白表达明显相关（P<0.05）。［结论］ LCN2在伴淋巴转移的喉鳞状细胞癌中表达明显增高，可能成为预测淋巴结转移的分子标志物。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of LCN2 in lymph node metastasis of laryngeal squamous cell carcinoma and its significance. ［Methods］ Fifty six samples of laryngeal carcinoma were acquired from Otolaryngological Department of Xianning Central Hospital. The LCN2 expression in primary tumor and lymph node was detected by immunohistochemistry. The relationship between LCN2 expression and tumor differentiation was analyzed by tissue microarray. ［Results］ The expression of LCN2 in patients with lymph node metastasis was higher than that in those without metastasis(P<0.05). The expression of LCN2 in highly differentiated laryngeal squamous cell carcinoma was low，and in poorly differentiated laryngeal squamous cell carcinoma was high，the LCN2 expression was correlated with tumor differentiation(P<0.05). ［Conclusion］ The expression of LCN2 is higher in laryngeal squamous cell carcinoma with lymph node metastasis，indicating that it may be used as a biomarker of lymph node metastasis. |
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