| 祁馨卉,栾玉婷,韩 涛.PRR11在肝癌中的表达及其与预后的关系[J].肿瘤学杂志,2018,24(8):769-773. |
| PRR11在肝癌中的表达及其与预后的关系 |
| Expression of Proline Rich Protein 11 in Hepatocellular Carcinoma and Its Relationship with Prognosis |
| 投稿时间：2017-07-02 |
| DOI：10.11735/j.issn.1671-170X.2018.08.B003 |
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| 中文关键词: PRR11 肝细胞肝癌 预后 |
| 英文关键词:PRR11 HCC prognosis |
| 基金项目:中国博士后科学基金面上项目（2015M582822）；辽宁省博士科研启动基金（201501022）；军队医学科技青年培育计划（15QNP005） |
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| 中文摘要: |
| 摘 要：［目的］ 研究肝癌组织中富含脯氨酸蛋白11(PRR11)表达与肝癌临床病理参数之间的关系，以及PRR11表达对肝癌患者预后的影响。［方法］ 通过构建含243例肝癌的组织芯片，用免疫组化方法检测PRR11蛋白在肝癌组织中的表达。［结果］ 243例肝癌组织标本中，PRR11高表达与性别、AFP水平、HBSAg、HBeAg水平有关。Kaplan-Meier 生存分析显示：PRR11高表达患者总生存期短于低表达患者(36.5个月vs 46.3个月，P=0.007) ，且病理分期(Ⅰ～Ⅱ vs Ⅲ～Ⅳ：60.7个月vs 19.5个月，P=0.001)、主瘤直径(≤5cm vs ＞5cm：55.9个月vs 19.5个月，P<0.001)、有无癌栓(无 vs 有：49.3个月 vs 22.7个月，P<0.001)、子灶数目(≤1个 vs ＞1个：50.0个月vs 22.5个月，P<0.001)与总生存期均显著相关。Cox风险回归模型分析显示PRR11表达是肝癌患者的独立预后因素（P=0.007)。［结论］ PRR11在部分肝癌组织中高表达，是肝癌患者独立的不良预后因素。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of proline protein 11(PRR11) in hepatocellular carcinoma(HCC) and its relationship with clinicopathological features and the prognosis of patients with HCC. ［Methods］ The expression of PRR11 protein was detected by immunohistochemical staining in tissue specimens of 243 HCC patients. ［Results］ The expression of PRR11 was positively correlated with gender，AFP level，HBsAg and HBeAg levels of HCC patients. Kaplan-Meier survival analysis showed that the overall survival (OS) in patients with low PRR11 expression was significantly longer than that in patients with high PRR11 expression (46.3months vs 36.5months，P=0.007). The OS was also significantly correlated with the pathological stage (Ⅰ～Ⅱ vs. Ⅲ～Ⅳ：60.7 months vs. 19.5 months，P=0.001)，tumor diameter (≤ 5cm vs ＞5cm：55.9months vs 19.5months，P<0.001)，tumor embolus (No vs Yes：49.3months vs 22.7months，P<0.001) and number of sub-foci (≤1 vs ＞1：50.0 months vs 22.5 months，P<0.001). Cox risk regression model analysis showed that PRR11 expression was an independent prognostic factor for HCC patients. ［Conclusion］ PRR11 is highly expressed in HCC tissues and is an independent prognostic factor for HCC patients. |
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