| 刘 冬,刘 冠.阿米福汀在盆腔放疗中的应用及研究进展[J].肿瘤学杂志,2018,24(7):734-738. |
| 阿米福汀在盆腔放疗中的应用及研究进展 |
| Research Progress on Application of Amifostine in Pelvic Radiotherapy |
| 投稿时间：2017-12-01 |
| DOI：10.11735/j.issn.1671-170X.2018.07.B016 |
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| 中文关键词: 阿米福汀 盆腔放疗 细胞保护 |
| 英文关键词:amifostine pelvic radiotherapy cytoprotection |
| 基金项目: |
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| 中文摘要: |
| 摘 要：阿米福汀作为一种选择性的细胞保护剂，现已广泛应用于临床。阿米福汀细胞保护机制复杂，主要通过活性代谢产物WR-1065发挥清除自由基的作用。虽然阿米福汀会导致恶心呕吐、体位性低血压等多种不良反应，但经适当的对症处理可有效缓解。多项临床研究证实，阿米福汀可经多种方式给药，减轻盆腔放疗患者相关毒性，且不影响患者总体预后。 |
| 英文摘要: |
| Abstract：Radiotherapy is one of the most important treatments for pelvic cancers. As a selective cytoprotector，amifostine has been widely used. The cytoprotective mechanisms of amifostine are quite complex. WR-1065，a active metabolite of amifostine，has the scavenger activity against free radicals produced by ionizing radiation or chemicals. The main adverse reactions of amifostine were nausea，vomiting and postural hypotension，which can be alleviated by symptomatic treatments. Many clinical studies have confirmed that amifostine can be administrated through various approached to attenuate the adverse reactions of pelvic radiation without affecting the prognosis of patients. |
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