黄 维,黄 蓝,夏百荣.组蛋白去乙酰化酶抑制剂在卵巢癌中的研究进展[J].肿瘤学杂志,2018,24(7):717-721. |
组蛋白去乙酰化酶抑制剂在卵巢癌中的研究进展 |
Progress of Histone Deacetylase Inhibitors in Ovarian Cancer |
投稿时间:2017-05-18 |
DOI:10.11735/j.issn.1671-170X.2018.07.B013 |
|
|
中文关键词: 组蛋白去乙酰化酶抑制剂 卵巢癌 转移 增殖 凋亡 |
英文关键词:histone deacetylase inhibitors ovarian cancer migration proliferation apoptosis |
基金项目: |
|
摘要点击次数: 2142 |
全文下载次数: 2236 |
中文摘要: |
摘 要:研究发现在基因的核苷酸序列不发生改变的情况下,基因表达发生的可遗传变化即表观遗传改变与卵巢癌的发生,发展密切相关。近年来,组蛋白去乙酰化酶抑制剂因主要抑制组蛋白去乙酰化酶功能,影响表观遗传改变,在卵巢癌细胞中具有抑制肿瘤生长、分化、促进癌细胞凋亡等作用备受关注。全文就组蛋白去乙酰化酶抑制剂在卵巢癌中的研究进展作一综述。 |
英文摘要: |
Abstract:It has been revealed that the heritable changes in gene expression without nucleotide sequence changes,or epigenetic changes are closely related to the occurrence and development of ovarian cancer. Research evidence has shown that histone deacetylase inhibitors would affect epigenetic changes in ovarian cancer cells,resulting in the inhibition of tumor growth and differentiation,and promoting apoptosis of cancer cells. This article reviews the recent progress of histone deacetylase inhibitors in ovarian cancer. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |