| 张光伟,刘也夫,于慧会.螺杆菌属与胆道恶性肿瘤关系meta分析[J].肿瘤学杂志,2018,24(7):710-716. |
| 螺杆菌属与胆道恶性肿瘤关系meta分析 |
| A Meta-analysis of Helicobacter Species Infection Associated with Biliary Tract Cancer |
| 投稿时间：2017-06-02 |
| DOI：10.11735/j.issn.1671-170X.2018.07.B012 |
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| 中文关键词: 胆管肿瘤 螺杆菌属 meta分析 |
| 英文关键词:bile duct tumor helicobacter meta-analysis |
| 基金项目:辽宁省自然科学基金项目（201602444） |
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| 摘要点击次数: 1784 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨螺杆菌属感染与胆道肿瘤的关系。［方法］ 进行系统文献检索，对地域分布、检测方法、标本、菌种、阳性种类进行meta分析。［结果］ 从1990年到2016年共纳入14篇病例对照研究，总体meta分析显示幽门螺杆菌感染和胆管癌之间有关联（累积OR=1.77，95％CI：1.53~2.06）。亚组分析显示：螺杆菌属中幽门螺杆菌、胆螺杆菌、肝螺杆菌在恶性组与良性组对比是有统计学意义的。基于地理分布表明幽门螺杆菌素不仅在高发地区，同样在低发地区（欧洲OR＝1.78，95％CI：1.25~2.52）也是危险因素。［结论］ 螺杆菌感染与胆管癌之间存在有关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between helicobacter infection and biliary tract tumors. ［Methods］A systematic review was carried out to identify all eligible articles. Meta analysis was performed on subgroup regional distribution，detection methods，specimens，strains and positive species. ［Results］ A total of 14 case-control studies were included from 1990 to 2016. Overall meta-analysis showed that there were association between helicobacter pylori infection and cholangiocarcinoma(cumulative OR=1.77，95%CI：1.53~2.06). Subgroup analysis showed that helicobacter was belonged to helicobacter pylori，and comparison between gall helicobacter and liver helicobacter in the malignant group and benign group was significant. Based on geographical distribution，helicobacter pylori was a risk factor not only in high incidence areas，but also in low birth areas(OR=1.78，95%CI：1.25~2.52 in Europe). ［Conclusions］ There is relationship between helicobacter infection and cholangiocarcinoma. |
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