| 吴锋杰,陈恩国,姚扬伟.CT引导下经皮射频消融治疗Ⅰ期非小细胞肺癌17例的疗效分析[J].肿瘤学杂志,2018,24(7):682-686. |
| CT引导下经皮射频消融治疗Ⅰ期非小细胞肺癌17例的疗效分析 |
| CT-Guided Percutaneous Radiofrequency Ablation for Patients with Clinical Stage I Non-small Cell Lung Cancer：Report of 17 cases |
| 投稿时间：2017-06-13 |
| DOI：10.11735/j.issn.1671-170X.2018.07.B006 |
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| 中文关键词: 肺肿瘤 射频消融 生存 |
| 英文关键词:lung neoplasms radiofrequency ablation survival |
| 基金项目:嘉兴市科技局公益类项目（2017AY33029） |
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| 摘要点击次数: 2045 |
| 全文下载次数: 477 |
| 中文摘要: |
| 摘 要：［目的］ 探讨CT引导下经皮射频消融治疗在Ⅰ期非小细胞肺癌患者的临床疗效及安全性。［方法］ 回顾性分析2011年1月至2016年12月期间在嘉兴市第二医院住院治疗并拒绝或无法耐受手术的17例Ⅰ期非小细胞肺癌患者，年龄51~90岁，平均年龄（68.3±8.6）岁，鳞癌3例，腺癌14例，肿块大小0.6~5cm，平均（3.5±1.3）cm。接受CT引导下经皮射频消融治疗，并观察其安全性和有效性。 ［结果］ 17例患者总共进行了20次射频消融治疗，消融时间9~30min，平均（21.6±5.7）min，技术成功率100%。随访时间11.5~71个月。中位生存期49个月，1、2、3年总生存率分别为94%、71%和64%。中位无进展生存期30个月，1、2、3年无进展生存率分别为88%、73%和52%。围手术期无严重并发症。［结论］ 临床Ⅰ期且不适合手术的非小细胞肺癌患者，射频消融是一种安全、可行、有效的治疗方法。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the clinical efficacy and safety of CT-guided percutaneous radiofrequency ablation in stage I non-small cell lung cancer (NSCLC). ［Methods］ Clinical data of 17 patients with stage Ⅰ NSCLC admitted in Jiaxing Second Municipal Hospital from January 2011 to December 2016 were retrospectively analyzed. The patients aged 68.3 ± 8.6 years (51~90 years) all rejected or did not tolerate surgery and alternatively received CT-guided percutaneous radiofrequency ablation. There were 14 cases of adenocarcinoma and 3 cases of squamous cell carcinoma with tumor mass size of 3.5±1.3cm(0.6~5cm). The safety and efficacy of radiofrequency ablation were evaluated. ［Results］ The ablation time was 9~30 min with an average of 21.6 ± 5.7 min. The technical success rate was 100%. The patients were followed up for 11.5~71 months. The median survival was 49 months，1-，2- and 3 years-overall survival rates were 94%，71%，and 64%，respectively. The median progression-free survival was 30 months，the 1-，2- and 3-years progression-free survival was 88%，73%，and 52%，respectively. ［Conclusion］ Radiofrequency ablation is a safe，feasible and effective treatment for patients with non -small cell lung cancer who are not suitable for surgical treatment. |
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