| 张扬帆,郝 尧.非小细胞肺癌患者血清中组织蛋白酶S降解的巢蛋白-1检测的临床意义[J].肿瘤学杂志,2018,24(7):672-675. |
| 非小细胞肺癌患者血清中组织蛋白酶S降解的巢蛋白-1检测的临床意义 |
| Clinical Significance of Serum Cathepsin S Degradation Nidogen-1 in Patients with Non-small Cell Lung Cancer |
| 投稿时间：2017-07-26 |
| DOI：10.11735/j.issn.1671-170X.2018.07.B004 |
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| 中文关键词: 非小细胞肺癌 巢蛋白-1 组织蛋白酶S 危险因素 |
| 英文关键词:non small cell lung cancer nidogen-1 cathepsin S risk factors |
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| 中文摘要: |
| 摘 要：［目的］ 探讨非小细胞肺癌（NSCLC）患者血清中组织蛋白酶S降解的巢蛋白-1定量检测的临床意义。［方法］ 选择2010年1月至2012年12月来接受手术切除治疗的NSCLC患者48例，另选择同期年龄、性别48人正常人群作为对照。应用酶联免疫吸附法检测NSCLC患者及对照组中血清巢蛋白-1表达水平。应用单因素、多因素非条件Cox回归分析分析影响NSCLC患者预后的危险因素分析。［结果］ 48例NSCLC患者中血清巢蛋白-1表达水平为（105.62±25.67）ng/ml，显著性高于对照组的（34.59±8.26）ng/ml（P＜0.05）。NSCLC患者中血清巢蛋白-1表达水平与临床病理特征的关系结果显示，血清巢蛋白-1高表达与性别、年龄、吸烟史、嗜酒史、组织类型无相关性（P＞0.05），与淋巴结转移、分化程度、TNM分期显著性相关（P＜0.05）。Kaplan-Meier生存分析结果显示，血清巢蛋白-1≤70ng/ml的NSCLC患者生存率显著性高于血清巢蛋白-1＞70ng/ml患者（P＜0.05）。多因素Cox回归分析结果显示，淋巴结转移、TNM分期、血清巢蛋白-1水平＞70ng/ml不利于NSCLC患者预后（P＜0.05）。［结论］ NSCLC患者中血清巢蛋白-1水平升高，血清巢蛋白-1水平可作为预测NSCLC患者预后的血清学标志物。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the clinical significance of quantitative detection of serum cathepsin S degradation nidogen-1 in non-small cell lung cancer(NSCLC）. ［Methods］ Forty-eight patients with NSCLC in our hospital from Jan 2010 to Dec 2012 were selected as study subjects，and 48 normal subjects of the same age and gender were selected as controls. Enzyme linked immunosorbent assay was used to detect the level of serum nidogen-1 in NSCLC patients and controls. Univariate and multivariate Cox regression analysis were used to analyze the risk factors of prognosis in patients with NSCLC. ［Results］ The expression of serum nidogen-1 in 48 patients with NSCLC was(105.62±25.67）ng/ml，which was significantly higher than that in control group(34.59±8.26）ng/ml(P<0.05）. The relationship between NSCLC patients with serum nidogen-1 expression and clinicopathological features showed no correlation between nidogen-1 level and gender，age，smoking history，drinking history，histological type(P>0.05），but was correlated significantly with lymph node metastasis，differentiation degree，TNM staging(P<0.05）. Kaplan-Meier survival analysis showed that survival of patients with NSCLC of serum levels of nestin-1≤70ng/ml was significantly higher than that of serum nestin-1>70ng/ml(P<0.05）. Cox regression analysis showed that lymph node metastasis，TNM staging Ⅲ~Ⅳ，serum nidogen-1 level>70ng/ml was the prognosis of patients with NSCLC(P<0.05）. ［Conclusion］ Serum nidogen-1 level is elevated in patients with NSCLC，and serum nidogen-1 level can be used as markers for predicting the prognosis of patients with NSCLC. |
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