| 中文关键词: 难治性，小细胞肺癌 化疗 耐药 |
| 英文关键词:refractory small cell lung cancer chemotherapy drug resistance |
| 基金项目:国家自然科学基金（81672931）；中国博士后科学基金(2016M591552) |
|
| 摘要点击次数: 2385 |
| 全文下载次数: 578 |
| 中文摘要: |
| 摘 要：小细胞肺癌( small cell lung cancer，SCLC) 是肺癌的一种特殊类型，与非小细胞肺癌相比，SCLC具有恶性程度高、侵袭性强、易发生转移的特点。SCLC对化疗和放疗都比较敏感，但化疗耐药的产生让SCLC治疗遭遇滑铁卢，其中难治性SCLC的治疗更加棘手。毫无疑问，难治性SCLC的治疗是肿瘤学界的重大挑战。全文中我们对难治性SCLC的定义、耐药机制及治疗进行叙述总结，希望为难治性SCLC的临床研究及治疗指引方向。 |
| 英文摘要: |
| Abstract：Small cell lung cancer（SCLC）is a special type of lung cancer. Compared with non-small cell lung cancer(NSCLC)，SCLC is a highly aggressive malignancy characterized by high cellular proliferation and early metastasis. SCLC usually is chemosensitive and radiosensitive；however，following the initial responsiveness to chemotherapy，the resistance to chemotherapy would develop and the treatment of refractory small cell lung cancer is more difficult，leading to the poor prognosis. In this review，we summarizes the definition of refractory SCLC，progress in resistant mechanism and its treatment. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |
