| 李 璐,谷建钟.肺癌多基因功能分析及调控网络模型的建立[J].肿瘤学杂志,2018,24(6):611-620. |
| 肺癌多基因功能分析及调控网络模型的建立 |
| Functional Analysis of Multiple Genes in Lung Cancer and Establishment of Regulatory Network |
| 投稿时间：2017-01-16 |
| DOI：10.11735/j.issn.1671-170X.2018.06.B016 |
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| 中文关键词: 肺肿瘤 MMP-7 功能分析 调控网络模型 细胞增殖 |
| 英文关键词:lung cancer MMP-7 functional analysis regulatory network cell proliferation |
| 基金项目:浙江省科技厅公益技术项目（2015C33172） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨肺癌多基因的功能，并建立肺癌细胞增殖调控网络模型。［方法］ 基于前期对MMP-7蛋白交联作用分析，利用基因本体论（Gene Ontology，GO）和基因组百科全书数据库（Kyoto Encyclopedia of Genes and Genomes，KEGG），对与之具有交联作用的ZBTB33、NGF、COL18A1、MMP-1、TIMP1、CTNNB1、JUP、CD44、SDC1、HBEGF进行功能分析和肺癌细胞增殖调控网络模型的建立。［结果］ 综合GO功能分析和KEGG分析结果，初步建立肺癌细胞增殖调控网络模型，并分析调控网络模型中基因的作用。［结论］ 成功构建上述基因在肺癌细胞增殖中的调控网络模型，为进一步研究肺癌发病机制及其治疗提供一定的理论基础。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the function of multiple genes in lung cancer and establish proliferation regulatory network of lung cancer cells. ［Methods］ Based on previous analysis of MMP-7’s cross linking，Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) were used to conduct functional analysis for genes cross linked to MMP-7，including ZBTB33，NGF，COL18A1，MMP-1，TIMP1，CTNNB1，JUP，CD44，SDC1，HBEGF，and to establish proliferation regulatory network. ［Results］ After synthesizing results of GO and KEGG analysis，proliferation regulatory network of lung cancer cells was preliminarily established and the roles that genes played in the network were analyzed. ［Conclusion］ The proliferation regulatory network of lung cancer cells including the above genes was successfully established，providing theoretical foundation for further study in pathogenesis of lung cancer and its treatment. |
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