李 璐,谷建钟.肺癌多基因功能分析及调控网络模型的建立[J].肿瘤学杂志,2018,24(6):611-620. |
肺癌多基因功能分析及调控网络模型的建立 |
Functional Analysis of Multiple Genes in Lung Cancer and Establishment of Regulatory Network |
投稿时间:2017-01-16 |
DOI:10.11735/j.issn.1671-170X.2018.06.B016 |
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中文关键词: 肺肿瘤 MMP-7 功能分析 调控网络模型 细胞增殖 |
英文关键词:lung cancer MMP-7 functional analysis regulatory network cell proliferation |
基金项目:浙江省科技厅公益技术项目(2015C33172) |
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中文摘要: |
摘 要:[目的] 探讨肺癌多基因的功能,并建立肺癌细胞增殖调控网络模型。[方法] 基于前期对MMP-7蛋白交联作用分析,利用基因本体论(Gene Ontology,GO)和基因组百科全书数据库(Kyoto Encyclopedia of Genes and Genomes,KEGG),对与之具有交联作用的ZBTB33、NGF、COL18A1、MMP-1、TIMP1、CTNNB1、JUP、CD44、SDC1、HBEGF进行功能分析和肺癌细胞增殖调控网络模型的建立。[结果] 综合GO功能分析和KEGG分析结果,初步建立肺癌细胞增殖调控网络模型,并分析调控网络模型中基因的作用。[结论] 成功构建上述基因在肺癌细胞增殖中的调控网络模型,为进一步研究肺癌发病机制及其治疗提供一定的理论基础。 |
英文摘要: |
Abstract:[Objective] To investigate the function of multiple genes in lung cancer and establish proliferation regulatory network of lung cancer cells. [Methods] Based on previous analysis of MMP-7’s cross linking,Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) were used to conduct functional analysis for genes cross linked to MMP-7,including ZBTB33,NGF,COL18A1,MMP-1,TIMP1,CTNNB1,JUP,CD44,SDC1,HBEGF,and to establish proliferation regulatory network. [Results] After synthesizing results of GO and KEGG analysis,proliferation regulatory network of lung cancer cells was preliminarily established and the roles that genes played in the network were analyzed. [Conclusion] The proliferation regulatory network of lung cancer cells including the above genes was successfully established,providing theoretical foundation for further study in pathogenesis of lung cancer and its treatment. |
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