| 姚 东,徐裕金,徐晓玲.SOST和β-catenin蛋白表达与非小细胞肺癌预后的相关性[J].肿瘤学杂志,2018,24(6):573-579. |
| SOST和β-catenin蛋白表达与非小细胞肺癌预后的相关性 |
| Relationship of SOST and β-catenin Protein Expression with Prognosis of Non-small Cell Lung Cancer |
| 投稿时间：2018-04-14 |
| DOI：10.11735/j.issn.1671-170X.2018.06.B009 |
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| 中文关键词: SOST β-Catenin 癌，非小细胞肺 预后 |
| 英文关键词:SOST β-catenin NSCLC prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 研究SOST与β-catenin蛋白表达与对非小细胞肺癌（non-small cell carcinoma，NSCLC）预后的相关性。［方法］ 614例NSCLC手术患者癌组织石蜡制作成组织芯片，免疫组化检测SOST与β-catenin蛋白表达。分析SOST、β-catenin蛋白表达与临床病理特征的相关性；Cox回归分析患者预后影响因素，采用Kaplan-Meier法及Log-rank检验分析临床病理特征及SOST、β-catenin蛋白表达与患者无疾病进展生存期(DFS)和总生存期(OS)的关系。［结果］ 614例患者中SOST、β-catenin蛋白表达阳性率分别为39.6%（243/614）、55.2%（339/614）；SOST表达与肿瘤的分化、分期、家族史、术前有无新辅助放化疗、淋巴结转移及骨转移均独立相关(P<0.05)，SOST蛋白阳性表达患者的DFS与OS较阴性表达患者好；β-Catenin蛋白表达与肿瘤分化、分期、淋巴结转移独立相关（P<0.05），β-Catenin蛋白阳性表达患者的DFS与OS较表达阴性患者低；SOST蛋白表达阳性患者中，β-Catenin蛋白表达阳性率降低。［结论］ SOST表达阳性者、β-Catenin表达阴性者具有更好的预后；SOST蛋白可能能抑制Wnt信号通路，降低β-Catenin蛋白表达；SOST和β-Catenin蛋白可能是判断NSCLC患者的独立预后因子。 |
| 英文摘要: |
| Abstract：［Objective］ To study the relationship of SOST and β-catenin protein expression with the prognosis of non-small cell lung cancer(NSCLC). ［Methods］ The expression of SOST and β-catenin protein was detected by immunohistochemistry on paraffin tissue microarray from 614 NSCLC patients. The relationship of SOST and β-catenin protein expression with the clinicopathological features of NSCLC patients was analyzed. The disease-free survival(DFS) and overall survival(OS) were determined by Kaplan-Meier method. The correlation of clinicopathological factors and expression of SOST and β-catenin protein with the DFS and OS were analyzed by COX regression and Log-rank test. ［Results］ The positive expression rate of SOST and β-catenin protein was 39.6%(243/614) and 55.2%(339/614) in the 614 patients，respectively. The expression of SOST was correlated with tumor differentiation，tumor stages，family history，new adjuvant chemoradiotherapy before operation，bone metastasis and lymph node metastasis(P<0.05)；the DFS and OS in positive SOST expression patients were better than those in negative patients. The expression of β-catenin protein was correlated with tumor differentiation，stages and lymph node metastasis(P<0.05)；the DFS and OS in β-catenin positive patients was poorer than those in negative expression patients. The positive rate of β-catenin protein was lower in patients with positive SOST expression. ［Conclusion］ Patients with positive SOST expression or negative β-catenin expression have better prognosis. And SOST and β-catenin protein may be independent prognostic factors in NSCLC patients. |
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