| 邱慧芝,王琳婧,莫浩元.905例鼻咽癌远期疗效及失败模式的探讨[J].肿瘤学杂志,2018,24(6):555-561. |
| 905例鼻咽癌远期疗效及失败模式的探讨 |
| Long-term Outcomes and Treatment Failure of 905 Nasopharyngeal Carcinoma Patients Treated with Radiotherapy |
| 投稿时间：2017-09-15 |
| DOI：10.11735/j.issn.1671-170X.2018.06.B006 |
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| 中文关键词: 鼻咽肿瘤 治疗失败 预后 |
| 英文关键词:nasopharyngeal carcinoma patterns of treatment failure prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 分析905例鼻咽癌患者的远期生存情况及治疗失败模式并探讨其预后因素。［方法］ 回顾性分析2004年10月至2005年12月中山大学肿瘤防治中心收治的905例经病理证实的初治无转移鼻咽癌患者的临床资料。采用 Kaplan-Meier 法进行生存分析，Cox 回归模型进行多因素预后分析。［结果］ 全组中位随访时间为118.6个月（1.6～152.4个月），5年及10年总生存率（OS）、无局部区域复发率(LRFS)、无远处转移生存率（DMFS）、无病生存率（DFS）分别为77%、91%、86%、79%和67%、88%、85%、75%。211例（23.3%）患者治疗失败，出现远处转移、局部复发、区域复发的患者分别为126例、82例、14例。远处转移（13.9%）最常见，其次是鼻咽局部复发（9.1%），颈部淋巴结复发（1.5%）较少。多因素分析显示T、N分期是影响总生存、无远处转移生存及无病生存的独立因素，年龄是影响总生存的独立因素。［结论］ 早期鼻咽癌治疗效果良好，但局部晚期患者治疗效果较差，远处转移是鼻咽癌治疗失败的首要原因。 |
| 英文摘要: |
| Abstract：［Objective］ To analyze the long-term outcomes and treatment failure patterns and to investigate the prognostic factors of 905 nasopharyngeal carcinoma patients.［Methods］ From October 2004 to December 2005，905 patients with histology-proven newly diagnosed non-metastatic nasopharyngeal carcinoma treated in Sun Yat-sen university cancer center were reviewed. Survival analysis was performed with Kaplan-Meier method. Multivariate prognostic factors were analyzed by Cox regression model．［Results］ During a median follow up of 118.6 months(range 1.6～152.4m). The 5，10-year OS，LRFS，DMFS and DFS were 77%，91%，86%，79% and 67%，88%，85%，75% respectively. Of 905 patients，211 patients developed failure after treatment. And 126，82，14 had developed distant metastasis，primary recurrence and regional nodal recurrence. Distant metastasis(13.9%) was the major failure after treatment，followed by primary recurrence(9.1%)，the rate of regional nodal recurrence(1.5%) was comparatively low. Multivariate analysis showed that T stage and N stage were independent prognostic factors for OS，DMFS and DFS；age was an independent prognostic factor for OS.［Conclusions］ Satisfactory survival outcomes are obtained in early-stage nasopharyngeal carcinoma patients，but patients with advanced stage had unfavorable survivals，distant failure is the most common failure pattern after treatment for NPC. |
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