陈俊青,陈占红,王晓稼.三阴性乳腺癌雄激素受体靶向治疗的研究进展[J].肿瘤学杂志,2018,24(5):499-503. |
三阴性乳腺癌雄激素受体靶向治疗的研究进展 |
Progress on Targeting Androgen Receptor in Triple Negative Breast Cancer |
投稿时间:2017-11-18 |
DOI:10.11735/j.issn.1671-170X.2018.05.B018 |
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中文关键词: 三阴性乳腺癌 雄激素受体 治疗靶点 |
英文关键词:triple negative breast cancer androgen receptor therapeutic target |
基金项目:浙江省医药卫生平台计划(2015DTA004);浙江省医药卫生一般研究计划(2013KYA026);浙江省自然科学基金(LQ13H160016) |
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中文摘要: |
摘 要:三阴性乳腺癌是一组特殊亚群的乳腺癌,侵袭性较强,不能从传统的内分泌治疗和抗Her-2靶向治疗获益,预后较差。近来研究表明,雄激素受体在三阴性乳腺癌的发生发展中扮演重要角色,雄激素受体有望成为新的治疗靶点。目前,针对三阴性乳腺癌雄激素受体的靶向治疗崭露头角。全文就雄激素受体在三阴性乳腺癌靶向治疗研究进展作一综述。 |
英文摘要: |
Abstract:Triple negative breast cancer(TNBC) is considered as a specific subtype characterized by more aggressive course and poorer overall survival,and can not benefit from traditional endocrine therapy and Her2-targeted therapy. Recent studies demonstrate that androgen receptor (AR) may play an important role in the tumorigenesis of TNBC and could serve as a promising therapeutic target in TNBC. At present,evidence targeting androgen receptor in TNBC is emerging. This review summarizes the current research and future development of therapeutic strategies targeting AR in TNBC. |
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