| 袁梅琴,王 增,吕汪霞.血清PECAM-1在Ⅳ期胃癌中的表达及意义[J].肿瘤学杂志,2018,24(5):476-479. |
| 血清PECAM-1在Ⅳ期胃癌中的表达及意义 |
| Serum PECAM-1 Levels in Stage Ⅳ Gastric Cancer and Its Significance |
| 投稿时间：2017-12-16 |
| DOI：10.11735/j.issn.1671-170X.2018.05.B013 |
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| 中文关键词: 胃肿瘤 PECAM-1 总生存期 ELISA |
| 英文关键词:gastric cancer PECAM-1 overall survival ELISA |
| 基金项目:国家自然科学基金青年项目（81602583）；浙江省医药卫生科技项目(2016KYB036)；浙江省医药卫生科技项目(2016KYB043) |
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| 中文摘要: |
| 摘 要：［目的］ 研究血清PECAM-1表达与胃癌患者预后的相关性，了解其在胃癌发生发展过程中的作用。［方法］ 入组初诊的Ⅳ期胃癌患者56例，经组织病理确诊、符合本研究入组标准，于入院后未经治疗前采取外周血5ml，运用酶联免疫法（ELISA法）检测外周血中PECAM-1蛋白的表达，分析胃癌患者外周血中PECAM-1蛋白表达水平与预后及临床病理特征的关系。［结果］ 56例患者的中位总生存时间(mOS)为446d。胃癌患者血清PECAM-1中位值为79.5ng/ml，以该值作为分界值将患者分为高浓度组和低浓度组，PECAM-1高浓度组的mOS低于PECAM-1低浓度组（360d vs 558d，P=0.012）。PECAM-1高浓度组与低浓度组间患者性别、年龄（≥60岁与<60岁）、一线化疗方案（XELOX与SOX）及周期数（≤4周期与>4周期）、是否接受二线以上化疗差异均无统计学意义，但PECAM-1低浓度组一线化疗疗效优于高浓度组（P=0.043）。［结论］ Ⅳ期胃癌患者血清PECAM-1水平与一线化疗疗效及预后生存可能相关，PECAM-1水平高者预后差，一线化疗疗效差。 |
| 英文摘要: |
| Abstract：［Objective］ To analyze the relationship between serum PECAM-1 levels and the prognosis in patients with stage Ⅳ gastric cancer. ［Methods］ Fifty-six patients with stage Ⅳ gastric cancer were enrolled. The serum levels of PECAM-1 was detected by enzyme-linked immunosorbent assay (ELISA). And the relationship of serum PECAM-1 levels with clinical features and survival was analyzed. ［Results］The median overall survival time(mOS) of patients was 446d and the median serum PECAM-1 level was 79.5ng/ml. The OS in patients with high PECAM-1 level (>79.5ng/ml) was lower than that in those with low PECAM-1(≤79.5ng/ml) (360d vs. 558d，P=0.012). There were no significant differences in gender，age(≥60 years or <60 years)，the first-line chemotherapy regimens(XELOX or SOX) and the number of cycles(≤4 cycles or >4 cycles)，and receiving further chemotherapy between patients with high and low PECAM-1 levels，but the efficacy of first-line chemotherapy in patients with low PECAM-1 was better than that in patients with high PECAM-1(P=0.043). ［Conclusion］ The serum PECAM-1 level may be related to the efficacy of first-line chemotherapy and the prognosis in patients with stage Ⅳ gastric cancer. |
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