| 金 一,姜大庆,赵 林.体质指数对绝经后ER阳性乳腺癌新辅助内分泌治疗预后的影响[J].肿瘤学杂志,2018,24(5):459-464. |
| 体质指数对绝经后ER阳性乳腺癌新辅助内分泌治疗预后的影响 |
| Body Mass Index on Survival of Breast Cancer Patient with Neoadjuvant Endocrine Therapy |
| 投稿时间：2017-05-02 |
| DOI：10.11735/j.issn.1671-170X.2018.05.B010 |
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| 中文关键词: 乳腺癌 新辅助内分泌治疗 体质指数 预后 |
| 英文关键词:breast cancer neoadjuvant endocrine therapy body mass index prognosis |
| 基金项目:国家自然科学基金项目（81572831） |
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| 摘要点击次数: 1770 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨体质指数（BMI）对绝经后ER阳性乳腺癌患者的新辅助内分泌疗效及对预后的影响。［方法］ 对118例经新辅助内分泌治疗乳腺癌患者进行回顾性分析，评估BMI对无病生存率和总生存率的影响。肥胖定义为BMI≥28kg/m2。生存分析采用Kaplan-Meier法和Log-rank检验，单因素和多因素分析采用Cox风险比例模型。［结果］ 118例乳腺癌均为绝经后女性，其中BMI≥28kg/m2 46例（38．9％），BMI＜28kg/m2 72例（61．1％）。BMI≥28kg/m2患者经新辅助内分泌治疗后有效率为56.5%（20/46），BMI＜28kg/m2患者有效率为62.5%（45/72），两组差异具有统计学意义（P=0.033）。中位随访时间39个月，BMI＜28kg/m2和BMI≥28kg/m2组乳腺癌患者的39个月无病生存率分别为91.7%和73.9%(P=0.008)；BMI＜28kg/m2和BMI≥28kg/m2乳腺癌患者的39个月总生存率分别为93.1%和80.4%，差异有统计学意义(P=0.013)。多因素分析显示，BMI≥28kg/m2是影响乳腺癌患者新辅助内分泌疗效和预后的不良因素。［结论］ 超重和肥胖是影响乳腺癌患者内分泌治疗效果和预后的不良因素。 |
| 英文摘要: |
| Abstract：Abstract：［Objective］ To analyze the relevance between body mass index(BMI) and survival of breast cancer after neoadjuvant endocrine therapy . ［Methods］ Retrospective analysis of 118 breast cancer patient after neoadjuvant endocrine therapy were conducted. The effect of BMI on disease-free survival(DFS) and overall survival(OS) in these patients were evaluated. Obesity was defined as a BMI≥28kg/m2. Kaplan-Meier analysis and Log-rank test were employed to perform survival analysis. The impact of different characteristics on survival was assessed by using Cox proportional-hazards regression model. ［Results］ In total 46(38.9％） patients were obese，and 72（61.1％） were non-obese. The effective rate was 56.5% in the group of BMI＜28kg/m2 and 62.5% in the group of BMI≥28kg/m2 after neoadjuvant endocrine therapy（P=0.033）. The median follow up time was 39 months. The estimated DFS was 91.7% for non-obese and 73.9% for obese patients(P=0.008)，and the estimated OS was 93.1% for non-obese and 80.4% for obese patients(P=0.013). Multivariate analysis indicated that obesity was an independent prognostic factor for DFS and OS. ［Conclusions］ BMI of postmenopausal breast cancer response to neoadjuvant endocrine therapy is effective indicator for predicting and is associated the poorer outcome in patient with breast cancer. |
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