| 刘秀荃,张新宇.多梳基因Bmi-1在腹部肿瘤中的研究进展[J].肿瘤学杂志,2018,24(4):384-388. |
| 多梳基因Bmi-1在腹部肿瘤中的研究进展 |
| Research Progress of Polycomb Group Bmi-1 Gene in Abdominal Tumor |
| 投稿时间：2017-07-01 |
| DOI：10.11735/j.issn.1671-170X.2018.04.B019 |
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| 中文关键词: Bmi-1 多梳基因 腹部肿瘤 |
| 英文关键词:Bmi-1 polycomb group abdominal tumor |
| 基金项目: |
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| 中文摘要: |
| 摘 要：多梳基因家族是由多种转录抑制子构成的调节基因，它主要和细胞周期及增殖有关。多梳基因Bmi-1在调节干细胞分裂和增殖等方面起着重要作用。目前发现Bmi-1基因在多种腹部肿瘤中高表达，可通过干扰Bmi-1基因表达抑制腹部肿瘤细胞增殖，Bmi-1可能成为腹部肿瘤生物治疗的新靶点。全文就Bmi-1在腹部肿瘤中的研究进展进行综述。 |
| 英文摘要: |
| Abstract：The comb gene family is a group of regulatory genes consisting of a variety of transcription inhibitors，mainly related to cell cycle and proliferation. Bmi-1 is one of the genes that play an important role in regulating stem cell division and proliferation. Bmi-1 gene is highly expressed in many abdominal tumors. This means that the proliferation of abdominal tumor cells can be inhibited if the expression of Bmi-1 gene is interfered with. Therefore，Bmi-1 may be a new target for biotherapy of abdominal tumor. Studies on Bmi-1 gene in abdominal tumors were summarized in this article. |
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