| 陈 栋,韩佃明,张 健.MiRNA-1297与AEG-1在肿瘤中的研究进展[J].肿瘤学杂志,2018,24(4):380-383. |
| MiRNA-1297与AEG-1在肿瘤中的研究进展 |
| Research Progress of MiRNA-1297 and AEG-1 in Tumors |
| 投稿时间：2017-01-03 |
| DOI：10.11735/j.issn.1671-170X.2018.04.B018 |
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| 中文关键词: 微小RNA miR-1297 肿瘤 星形细胞上调基因-1 |
| 英文关键词:MicroRNA MiR-1297 tumor AEG-1 |
| 基金项目: |
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| 中文摘要: |
| 摘 要：MircoRNA是一种基因表达的调节剂，其表达的改变导致癌基因的激活或肿瘤抑制基因的失活。星形细胞上调基因-1（AEG-1）被认为是一种癌基因，具有调节各种人类癌症中的细胞增殖、转移、转化、血管生成和放化疗抗性等，已经在乳腺癌、肝癌、前列腺等多种癌细胞中发现过表达，且与肿瘤进展相关的PI3K-AKT、NF-κB、MAPK和Wnt多种信号通路中发挥作用。miR-1297是一种具有肿瘤抑制作用的mircoRNA，其抑制或过表达影响与肿瘤增殖、侵袭有关的AEG-1、PTEN、Meg3等基因。 |
| 英文摘要: |
| Abstract：MircoRNA is a modulator of gene expression. The changes of its expression may result in activation of oncogenes or inactivation of tumor suppressor genes. AEG-1 is an oncogene that regulates cell proliferation，metastasis，transformation，angiogenesis，and resistance to chemoradiotherapy in a variety of human cancers. The over-expression of AEG-1 has been detected in breast cancer，liver cancer，prostate and other cancer cells，which plays a critical role in tumor-associated signaling pathways，such as PI3K-AKT，NF-kB，MAPK and Wnt. MiR-1297 is thought as a tumor suppressor mircoRNA，its inhibition or over-expression may affect tumor proliferation and invasion related genes，like AEG-1，PTEN，Meg3 and others. |
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