陈 栋,韩佃明,张 健.MiRNA-1297与AEG-1在肿瘤中的研究进展[J].肿瘤学杂志,2018,24(4):380-383.
MiRNA-1297与AEG-1在肿瘤中的研究进展
Research Progress of MiRNA-1297 and AEG-1 in Tumors
投稿时间:2017-01-03  
DOI:10.11735/j.issn.1671-170X.2018.04.B018
中文关键词:  微小RNA  miR-1297  肿瘤  星形细胞上调基因-1
英文关键词:MicroRNA  MiR-1297  tumor  AEG-1
基金项目:
作者单位
陈 栋 滨州医学院临床学院 
韩佃明 滨州医学院临床学院 
张 健 临沂市人民医院 
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中文摘要:
      摘 要:MircoRNA是一种基因表达的调节剂,其表达的改变导致癌基因的激活或肿瘤抑制基因的失活。星形细胞上调基因-1(AEG-1)被认为是一种癌基因,具有调节各种人类癌症中的细胞增殖、转移、转化、血管生成和放化疗抗性等,已经在乳腺癌、肝癌、前列腺等多种癌细胞中发现过表达,且与肿瘤进展相关的PI3K-AKT、NF-κB、MAPK和Wnt多种信号通路中发挥作用。miR-1297是一种具有肿瘤抑制作用的mircoRNA,其抑制或过表达影响与肿瘤增殖、侵袭有关的AEG-1、PTEN、Meg3等基因。
英文摘要:
      Abstract:MircoRNA is a modulator of gene expression. The changes of its expression may result in activation of oncogenes or inactivation of tumor suppressor genes. AEG-1 is an oncogene that regulates cell proliferation,metastasis,transformation,angiogenesis,and resistance to chemoradiotherapy in a variety of human cancers. The over-expression of AEG-1 has been detected in breast cancer,liver cancer,prostate and other cancer cells,which plays a critical role in tumor-associated signaling pathways,such as PI3K-AKT,NF-kB,MAPK and Wnt. MiR-1297 is thought as a tumor suppressor mircoRNA,its inhibition or over-expression may affect tumor proliferation and invasion related genes,like AEG-1,PTEN,Meg3 and others.
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