| 王 微,王慜杰,齐 军.北京地区血清肿瘤标志物SCC-Ag、CA72-4、AFP参考区间的初步建立[J].肿瘤学杂志,2018,24(4):365-369. |
| 北京地区血清肿瘤标志物SCC-Ag、CA72-4、AFP参考区间的初步建立 |
| Establishment of Reference Intervals of SCC-Ag，CA72-4，and AFP in Beijing |
| 投稿时间：2017-03-28 |
| DOI：10.11735/j.issn.1671-170X.2018.04.B015 |
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| 中文关键词: 肿瘤标志物 鳞状细胞癌相关抗原 糖类抗原72-4 甲胎蛋白 参考区间 |
| 英文关键词:tumor marker squamous cell carcinoma antigen(SCC-Ag) CA724 alpha fetal protein(AFP) reference interval |
| 基金项目:北京希望马拉松基金（LC2012A05） |
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| 中文摘要: |
| 摘 要：［目的］ 初步建立适合北京地区健康人群血清肿瘤标志物鳞状细胞癌相关抗原(SCC-Ag)、糖类抗原72-4（CA72-4）和甲胎蛋白(AFP)的参考区间，协助肿瘤辅助诊断、疗效判断以及预后评估。［方法］ 选取中国医学科学院肿瘤医院2012年10月至2015年4月的北京地区健康体检者，共计1068人，使用雅培Abbott i2000SR全自动免疫分析仪检测血清SCC-Ag的水平，使用罗氏Cobas e601全自动免疫分析仪检测血清CA72-4和AFP的水平。按照CLSI EP28-A3c推荐的统计学方法进行分析。［结果］ 血清SCC-Ag、CA72-4和AFP的参考区间分别为0～1.50 ng/ml、0～12.97U/ml和0～5.61ng/ml。SCC-Ag男性组高于女性组，分别为0～1.60ng/ml和0～1.44 ng/ml，需根据年龄和性别进行分组。AFP无需根据性别分组，但需根据年龄分组，且AFP参考范围随年龄增加而呈现上升趋势。［结论］ 初步确定了北京地区健康人血清肿瘤标志物SCC-Ag、CA72-4、AFP的参考区间。 |
| 英文摘要: |
| Abstract：［Objective］ To establish reference intervals of squamous cell carcinoma antigen(SCC-Ag)，CA724，and alpha fetal protein(AFP) for healthy individuals in Beijing so as to facilitate early diagnosis，effect evaluation，and prognosis estimation. ［Methods］ A total of 1068 healthy individuals were recruited from Cancer Hospital，Chinese Academy of Medical Sciences in Beijing between October，2012 and April，2015. Serum SCC-Ag was measured using Abbott Architect i2000SR analyzer，and serum CA724 and AFP were measured using Roche Cobas e601 automatic immunity analyzer. Reference intervals were calculated according to CLSI EP28-A3c guidelines. ［Results］ The 95th percentile reference intervals for SCC-Ag，CA724，and AFP were 0～1.50ng/ml，00～12.97U/ml，and 0～5.47ng/ml，respectively. Serum SCC-Ag level was significantly higher in men(0～1.60ng/ml) than that in women(0～1.44ng/ml). Reference intervals of serum SCC-Ag should be established according to age and sex. Reference intervals of AFP should be established according to age and should be elevated as with the increase in age. ［Conclusions］ The preliminarily reference intervals of SCC-Ag，CA724，and AFP for healthy individuals in Beijing are established． |
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