| 孙莎莎,邱 杰,赵 涵.ZNF703和CD44v6在甲状腺乳头状癌中的表达和意义[J].肿瘤学杂志,2018,24(4):303-307. |
| ZNF703和CD44v6在甲状腺乳头状癌中的表达和意义 |
| Expression of ZNF703 and CD44v6 Proteins in Papillary Thyroid Carcinoma and Their Clinical Significance |
| 投稿时间：2017-10-26 |
| DOI：10.11735/j.issn.1671-170X.2018.04.B003 |
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| 中文关键词: ZNF703 CD44v6 甲状腺乳头状癌 免疫组化 |
| 英文关键词:ZNF703 CD44v6 papillary thyroid carcinoma immunohistochmistry |
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| 摘要点击次数: 2027 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨 ZNF703和CD44v6在甲状腺乳头状癌中的表达和临床意义。［方法］ 应用免疫组化方法(SP法)检测ZNF703和CD44v6蛋白在甲状腺乳头状癌组织(40例)、配对癌旁正常甲状腺组织(40例)和结节性甲状腺肿组织(30例)中的表达，并探讨其与甲状腺乳头状癌临床病理特征的关系。［结果］ （1）ZNF703和CD44v6在甲癌组(67.5%、75.0%)的表达均高于癌旁组(7.5%、10.0%)和结甲组(30.0%、13.3%)，差异均有统计学意义(P均＜0.05)。（2）甲状腺癌组织中ZNF703和CD44v6的表达与肿瘤分期(TNM分期）和淋巴结转移有关(P＜0.05)；ZNF703和CD44v6的表达与患者的年龄和性别无关(P＞0.05)；ZNF703表达与肿瘤直径有关(P＜0.05)，直径＞1cm组较直径≤1cm组的表达阳性率高；CD44v6表达与肿瘤直径无关(P＞0.05)。（3）ZNF703和CD44v6蛋白在甲状腺癌组织中的表达呈正相关 (r=0.462，P＜0.05)。［结论］ ZNF703和CD44v6的表达与甲状腺乳头状癌的癌变、肿瘤分期和淋巴转移具有相关性，联合检测可能对甲状腺癌的诊疗和预后评估具有指导意义。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression and clinical significance of ZNF703 and CD44v6 proteins in papillary thyroid carcinoma. ［Methods］ The expressions of ZNF703 and CD44v6 proteins were detected in 40 samples of papillary thyroid carcinoma，40 samples of corresponding normal thyroid tissues and 30 samples of nodular goiter issues by immunohistochmistry(streptavidine-peroxidase method)，and its relationship with the clinicopathological features was analyzed. ［Results］ The expressions of ZNF703 and CD44v6 proteins in the papillary thyroid carcinoma(67.5%，75.0%) were significantly high than those in the corresponding normal thyroid tissues(7.5%，10.0%) and nodular goiter tissues(30.0%，13.3%)(all P＜0.05). The expressions of ZNF703 and CD44v6 proteins in the papillary thyroid carcinoma were correlated with lymph node metastasis and TNM stage(P＜0.05)，and were not correlated with the gender and age of patients(P＞0.05). The expression of ZNF703 proteins was correlated with the diameter of tumor(P＜0.05)；the positive rate of ZNF703 in diameter> 1cm group was higher than that in diameter≤1cm group. The expression of CD44v6 proteins in the papillary thyroid carcinoma was not correlated with the tumor size(P＞0.05). There was a positive correlation between the expression of ZNF703 and CD44v6 protein in papillary thyroid cancer(r=0.462，P<0.05). ［Conclusion］ The expression of ZNF703 and CD44v6 is correlated with clinical stages and lymphatic metastasis of thyroid papillary carcinoma，and combined detection of two proteins may be of value in the diagnosis and prognosis of thyroid cancer. |
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