| 吴 秋,杜远耀,付 毅.HIF-2α和Securin作为乳腺癌术后无瘤生存率预测指标的临床研究[J].肿瘤学杂志,2018,24(3):208-212. |
| HIF-2α和Securin作为乳腺癌术后无瘤生存率预测指标的临床研究 |
| Expression of HIF-2α and Securin for Predicting Disease-free Survival of Patients with Breast Cancer |
| 投稿时间：2017-02-21 |
| DOI：10.11735/j.issn.1671-170X.2018.03.B006 |
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| 中文关键词: 乳腺癌 HIF-2α securin 无瘤生存率 |
| 英文关键词:breast cancer HIF-2α securin disease-free survival |
| 基金项目:2014年度大学生科学研究与创新实验项目（201408） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨缺氧诱导因子-2α（HIF-2α）与securin在乳腺癌组织中的表达及其对无瘤生存率的意义。［方法］ 采用免疫组化SP法检测70例乳腺癌组织中HIF-2α和securin的表达，并分析其与乳腺癌临床疾病特征的关系及相关性。对患者进行无瘤生存期的随访，Kaplan Meier生存曲线分析HIF-2α和securin对无瘤生存期的意义。［结果］ 70例乳腺癌组织中 HIF-2α和securin阳性率、高表达率分别为30.0%（21/70）和34.3%（24/70）。Spearman相关分析表明，HIF-2α与securin的表达呈正相关（r=0.381，P=0.001）。Securin高表达和HIF-2α阳性与乳腺癌患者绝经情况、雌激素受体、孕酮受体、Her-2、淋巴结转移、ki67、TNM分期和肿瘤大小均无关（P>0.05）。Kaplan Meier生存曲线表明，HIF-2α阳性患者的无瘤生存期明显高于阴性患者。Cox模型多因素生存分析结果显示，HIF-2α是乳腺癌无瘤生存期的独立影响因素（P<0.05）。［结论］ HIF-2α和securin与乳腺癌的发生、发展密切相关，尤其是HIF-2α可能成为判断乳腺癌术后无瘤生存率的独立有效指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of HIF-2α and securin in breast cancer and its relation to disease-free survival. ［Methods］ The expression of HIF-2α and securin was detected by SP immunohistochemistry in 70 patients with breast cancer. The disease-free survival(DFS) of patients was examined by Kaplan-Meier survival curve and the relationship of HIF-2α and securin expression with clinical features and DFS was analyzed. ［Results］ The expressions of HIF-2α and securin were 30.0%（21/70）and 34.3%（24/70）in breast cancer，respectively. Spearman correlation analysis revealed that HIF-2α and securin were significantly correlated with each other(r=0.381，P=0.001). The expression of HIF-2α or securin was not correlated with menopausal status，PR，ER，HER-2，lymphatic metastasis，Ki67，TNM and size of tumor(all P>0.05). Kaplan-Meier survival curve showed the DFS of patients with HIF-2α positive expression was higher than those with negative expression. Cox regression model analysis revealed that HIF-2α was an independent prognostic factor of disease free survival(P<0.05). ［Conclusion］ The expression of HIF-2α was closely correlated with securin in breast cancer. HIF-2α may be an independent protective factor of disease-free survival in postoperative patients with breast cancer. |
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