| 刘思诗,陈可心,耿敬姝.应用2013年ASCO/CAP指南对Her-2IHC2+乳腺癌患者进行Her-2FISH分类[J].肿瘤学杂志,2018,24(3):203-207. |
| 应用2013年ASCO/CAP指南对Her-2IHC2+乳腺癌患者进行Her-2FISH分类 |
| Her-2 FISH Classification of Equivocal Her-2 IHC Breast Cancer with 2013 ASCO/CAP Guideline |
| 投稿时间：2017-04-23 |
| DOI：10.11735/j.issn.1671-170X.2018.03.B005 |
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| 中文关键词: Her-2 FISH IHC2+ ASCO/CAP指南 |
| 英文关键词:Her-2 FISH IHC2+ 2013 ASCO/CAP guideline |
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| 中文摘要: |
| 摘 要：［目的］探讨2013年ASCO/CAP指南对IHC2+乳腺癌患者Her-2FISH分类的影响。［方法］ 采用荧光原位杂交法检测173例Her-2免疫组化2+的乳腺癌患者的Her-2基因的状态并应用2013年ASCO/CAP指南的标准对检测结果进行分析。［结果］ 与2007年检测指南相比，使用2013年检测指南使36例患者发生了变化，取得了较高的阳性率（28.3% vs. 23.1%）和不确定率（16.2% vs. 4.0%），阴性比例下降（55.5% vs. 72.8%）。［结论］ 2013年指南的使用提高了阳性率和不确定患者的比例，从而提高了Her-2靶向治疗的病例数。FISH对于IHC2+的患者能够起到最后分类的作用，而17号染色体多体在FISH不确定的患者中占很大的比例。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the ASCO/CAP guidelines for 2013 IHC2+ Her-2 FISH breast cancer classification. ［Methods］ Using fluorescence in situ-hybridization method to detect 173 cases of Her-2 immunohistochemical 2+ breast cancer patients in the state of the Her-2 gene ASCO/CAP guidelines of 2013 standard and applied to analyze test results.［Results］ Compared with the testing guidelines in 2007，and 2013 were used to detect guidelines also resulted in the changes of 36 patients，the higher positive rate (28.3% vs. 23.1%) and the uncertain rate (16.2% vs. 4.0%)，negative percentage (55.5% vs. 72.8%).［Conclusion］ 2013 guidelines can improve the positive rate and the proportion of patients with uncertain，thus raise the number of cases of Her-2 targeted therapy，FISH for IHC2+ patients can have the effect of the final classification，and polysomy 17 in FISH make up a large proportion of patients with uncertainty. |
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