| 孔天东,段方方,王留晏.晚期三阴性乳腺癌TUBB3基因表达及与化疗疗效间关系[J].肿瘤学杂志,2018,24(3):195-198. |
| 晚期三阴性乳腺癌TUBB3基因表达及与化疗疗效间关系 |
| Relationship Between TUBB3 Expression with Chemotherapeutic Efficacy in Patients with Advanced Triple-negative Breast Cancer |
| 投稿时间：2017-06-04 |
| DOI：10.11735/j.issn.1671-170X.2018.03.B003 |
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| 中文关键词: 三阴性乳腺癌 TUBB3 化疗疗效 |
| 英文关键词:triple-negative breast cancer TUBB3 liquid phase chip |
| 基金项目:郑州市科技攻关计划(20130532) |
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| 摘要点击次数: 1826 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨TUBB3基因在晚期三阴性乳腺癌中的表达情况，及其与化疗疗效关系。［方法］ 回顾性分析晚期三阴性乳腺癌患者97例，检测患者肿瘤标本TUBB3 mRNA表达量，分析TUBB3mRNA与临床特征及化疗疗效的关系。 ［结果］ TUBB3 mRNA表达水平与患者的年龄、月经状态、转移部位、Ki67指数及PS评分无明显相关性，但与组织学分级相关。TUBB3 mRNA表达水平与紫杉类疗效关系密切，低表达者疗效好。Logistic分析表明三阴性乳腺癌化疗疗效与腋窝转移状态、Ki67及TUBB3 mRNA表达相关。［结论］ TUBB3基因有望成为晚期三阴性乳腺癌化疗疗效的预测基因，值得进一步研究。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between TUBB3 mRNA expression and chemotherapeutic efficacy in patients with advanced triple-negative breast cancer. ［Methods］ Clinical data of 97 patients with advanced triple-negative breast cancer treated with TAC，TP，or TX schemes were retrospectively analyzed. The expression of TUBB3 mRNA was detected by liquid chip technique，and the relationship between TUBB3 gene expression and efficacy of chemotherapy was analyzed. ［Results］ The expression of TUBB3 mRNA in triple-negative breast cancer patients was not correlated with age，menstrual status，metastatic sites，Ki67 and PS score(all P>0.05); it was positively correlated with histological grade(P=0.028) and negatively correlated with the efficacy of taxanes therapy. Logistic analysis showed that the efficacy of chemotherapy was associated with axillary lymph node metastasis，Ki67 index and TUBB3 mRNA expression. ［Conclusion］ TUBB3 gene expression is negatively associated with efficacy of chemotherapy，which might be used as a predictor for chemotherapy in patients with triple-negative breast cancer. |
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