| 谢 美,邹晓玲,晋 帅.细胞周期素D1 G870A基因多态性与胃癌易感性关系的Meta分析[J].肿瘤学杂志,2018,24(2):97-103. |
| 细胞周期素D1 G870A基因多态性与胃癌易感性关系的Meta分析 |
| The Association between CyclinD1 Gene G870A Polymorphism and the Risk of Gastric Cancer：A Meta-analysis |
| 投稿时间：2017-05-22 |
| DOI：10.11735/j.issn.1671-170X.2018.02.B004 |
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| 中文关键词: 胃肿瘤 细胞周期蛋白D1 G870A基因 多态性 Meta 分析 |
| 英文关键词:gastric cancer cyclinD1 G870A polymorphism meta-analysis |
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| 摘要点击次数: 1586 |
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| 中文摘要: |
| 摘 要：［目的］采用Meta 分析方法研究细胞周期素D1（CCND1）基因G870A多态性与胃癌易感性的关系。［方法］ 通过关键词与主题词检索PubMed，Ovid，CNKI，维普和万方数据库中有关CCND1基因G870A多态性与胃癌易感性的相关性研究，数据分析应用Review Manager 5.3和STATA 10.0 软件。［结果］ 纳入6篇文献，包括7个病例-对照试验研究，共计1283例胃癌患者为病例组与1760例非肿瘤患者为对照组。Meta分析结果显示，总人群中，CCND1基因G870A多态性与胃癌发生风险之间无显著相关性（A vs G：OR=0.90，95%CI：0.77～1.06，P=0.21；AA+AG vs GG：OR=0.85，95%CI：0.60～1.21，P=0.37；AG+GG vs AA：OR=1.15，95%CI：0.97～1.37，P=0.10）。在种族与肿瘤类型的亚组分层分析中，结果同样显示CCND1基因G870A多态性与胃癌的发生风险无明显相关性。［结论］ CCND1基因G870A多态性可能与胃癌的发生风险无关。 |
| 英文摘要: |
| Abstract：［Objective］To investigate the association between CCND1 G870A polymorphism and the risk of gastric cancer(GC).［Methods］ Databases including the PubMed，Ovid，CNKI，WeiPu，and WanFang(covering all publications)were searched. Statistical analyses were performed using Review Manager 5.3 software and STATA 10.0.［Results］A total of 1283 cases and 1760 controls in seven studies of six publications were included in this meta-analysis. The results showed no significant associations between CCND1G870A polymorphism and GC risk(A vs G：OR=0.90，95%CI：0.77～1.06，P=0.21；AA+AG vs GG：OR=0.85，95%CI：0.60～1.21，P=0.37；AG+GG vs AA：OR=1.15，95%CI：0.97～1.37，P=0.10). Likewise，no relation was identifiedin the subgroup analysis between GC susceptibility and the subdivision of ethnicity(Asians，Caucasians) and cancer type［cardiac adenocarcinoma(CAC)，GC(gastric cancer except CAC or not mentioned)］.［Conclusion］The CCND1 G870A polymorphism in CCND1 gene may not increase the risk of GC. |
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