谢 美,邹晓玲,晋 帅.细胞周期素D1 G870A基因多态性与胃癌易感性关系的Meta分析[J].肿瘤学杂志,2018,24(2):97-103.
细胞周期素D1 G870A基因多态性与胃癌易感性关系的Meta分析
The Association between CyclinD1 Gene G870A Polymorphism and the Risk of Gastric Cancer:A Meta-analysis
投稿时间:2017-05-22  
DOI:10.11735/j.issn.1671-170X.2018.02.B004
中文关键词:  胃肿瘤  细胞周期蛋白D1 G870A基因  多态性  Meta 分析
英文关键词:gastric cancer  cyclinD1 G870A  polymorphism  meta-analysis
基金项目:
作者单位
谢 美 成都中医药大学附属医院 
邹晓玲 成都中医药大学附属医院 
晋 帅 成都中医药大学附属医院 
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中文摘要:
      摘 要:[目的]采用Meta 分析方法研究细胞周期素D1(CCND1)基因G870A多态性与胃癌易感性的关系。[方法] 通过关键词与主题词检索PubMed,Ovid,CNKI,维普和万方数据库中有关CCND1基因G870A多态性与胃癌易感性的相关性研究,数据分析应用Review Manager 5.3和STATA 10.0 软件。[结果] 纳入6篇文献,包括7个病例-对照试验研究,共计1283例胃癌患者为病例组与1760例非肿瘤患者为对照组。Meta分析结果显示,总人群中,CCND1基因G870A多态性与胃癌发生风险之间无显著相关性(A vs G:OR=0.90,95%CI:0.77~1.06,P=0.21;AA+AG vs GG:OR=0.85,95%CI:0.60~1.21,P=0.37;AG+GG vs AA:OR=1.15,95%CI:0.97~1.37,P=0.10)。在种族与肿瘤类型的亚组分层分析中,结果同样显示CCND1基因G870A多态性与胃癌的发生风险无明显相关性。[结论] CCND1基因G870A多态性可能与胃癌的发生风险无关。
英文摘要:
      Abstract:[Objective]To investigate the association between CCND1 G870A polymorphism and the risk of gastric cancer(GC).[Methods] Databases including the PubMed,Ovid,CNKI,WeiPu,and WanFang(covering all publications)were searched. Statistical analyses were performed using Review Manager 5.3 software and STATA 10.0.[Results]A total of 1283 cases and 1760 controls in seven studies of six publications were included in this meta-analysis. The results showed no significant associations between CCND1G870A polymorphism and GC risk(A vs G:OR=0.90,95%CI:0.77~1.06,P=0.21;AA+AG vs GG:OR=0.85,95%CI:0.60~1.21,P=0.37;AG+GG vs AA:OR=1.15,95%CI:0.97~1.37,P=0.10). Likewise,no relation was identifiedin the subgroup analysis between GC susceptibility and the subdivision of ethnicity(Asians,Caucasians) and cancer type[cardiac adenocarcinoma(CAC),GC(gastric cancer except CAC or not mentioned)].[Conclusion]The CCND1 G870A polymorphism in CCND1 gene may not increase the risk of GC.
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