高云飞,罗洞波,刘 翼.胸腹腔镜对食管癌根治术患者炎症因子、肺功能及预后的影响[J].肿瘤学杂志,2018,24(1):42-46.
胸腹腔镜对食管癌根治术患者炎症因子、肺功能及预后的影响
Serum Levels of Inflammatory Factors,Lung Function and Prognosis in Patients with Esophageal Cancer After Endoscopy-assisted Radical Esophagectomy
投稿时间:2017-03-03  
DOI:10.11735/j.issn.1671-170X.2018.01.B009
中文关键词:  胸腔镜  腹腔镜  食管癌根治术  肺功能  炎症因子  预后
英文关键词:video assisted thoracic surgery  laparoscopy  esophageal cancer  lung function  inflammatory factor  prognosis
基金项目:
作者单位
高云飞 新疆医科大学附属肿瘤医院 
罗洞波 新疆医科大学附属肿瘤医院 
刘 翼 新疆医科大学附属肿瘤医院 
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中文摘要:
      摘 要:[目的] 探讨胸腹腔镜联合食管癌根治术对患者肺功能、血清炎症因子水平及患者预后的影响。[方法] 选取2011年10月至2014年12月实施食管癌根治手术的112例患者,根据手术方法分为胸腔镜联合腹腔镜辅助下的食管癌根治术(腔镜组)51例、采取传统开胸手术治疗的61例(传统组),对比两组的围手术期指标、术后炎症因子、肺功能及预后情况。[结果] 腔镜组患者的手术时间、手术出血量、术后引流量、住院时间均低于传统组患者(P<0.05),两组患者的清扫淋巴结数目比较差异无统计学意义(P>0.05);术后2周腔镜组FEV1、FEV1/FVC均高于传统组(P<0.05);术后5d腔镜组IL-8、TNF-α、IL-10均低于传统组(P<0.05);术后随访24个月,腔镜组的肿瘤复发率为41.18%、生存率为68.63%;而传统组分别为31.15%和73.77%。[结论] 胸腹腔镜联合食管癌根治术对患者肺功能影响小,术后患者的炎症反应程度轻,手术效果与开胸手术相当。
英文摘要:
      Abstract:[Objective] To investigate the lung function,serum levels of inflammatory factors and prognosis of patients with esophageal cancer after thoracoscopy- and laparoscopy-assissted radical esophagectomy. [Methods] One hundred and twelve patients with esophageal cancer undergoing surgical treatment from October 2011 to December 2014 were enrolled in the study,among whom 51 cases received thoracoscopy- and laparoscopy-assisted radical esophagectomy(study group) and 61 cases received conventional thoracotomy(control group). Perioperative indicators,pulmonary function and serum inflammatory factor levels and prognosis of patients were compared between two groups. [Results] The operation time,intraoperative blood loss,postoperative drainage,length of hospital stay in study group were all lower than those in control group(P<0.05). There was no significant difference in the number of lymph nodes dissected between two groups(P>0.05). Two weeks after surgery,the FEV1 and FEV1/FVC in study group was higher than those in control group(P<0.05);5 days after surgery serum IL-8,TNF-α,IL-10 levels in study group were lower than those in control group(P<0.05). During the 24-month follow-up,the recurrence rates in study group and control group were 41.18% and 31.15%; the survival reates were 68.63% and 73.77%,respectively. [Conclusion] The impact of endoscopy-assisted thoracic surgery on lung function and inflammation status in patients with esophageal cancer is limited.
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