| 高云飞,罗洞波,刘 翼.胸腹腔镜对食管癌根治术患者炎症因子、肺功能及预后的影响[J].肿瘤学杂志,2018,24(1):42-46. |
| 胸腹腔镜对食管癌根治术患者炎症因子、肺功能及预后的影响 |
| Serum Levels of Inflammatory Factors，Lung Function and Prognosis in Patients with Esophageal Cancer After Endoscopy-assisted Radical Esophagectomy |
| 投稿时间：2017-03-03 |
| DOI：10.11735/j.issn.1671-170X.2018.01.B009 |
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| 中文关键词: 胸腔镜 腹腔镜 食管癌根治术 肺功能 炎症因子 预后 |
| 英文关键词:video assisted thoracic surgery laparoscopy esophageal cancer lung function inflammatory factor prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胸腹腔镜联合食管癌根治术对患者肺功能、血清炎症因子水平及患者预后的影响。［方法］ 选取2011年10月至2014年12月实施食管癌根治手术的112例患者，根据手术方法分为胸腔镜联合腹腔镜辅助下的食管癌根治术（腔镜组）51例、采取传统开胸手术治疗的61例（传统组），对比两组的围手术期指标、术后炎症因子、肺功能及预后情况。［结果］ 腔镜组患者的手术时间、手术出血量、术后引流量、住院时间均低于传统组患者（P<0.05），两组患者的清扫淋巴结数目比较差异无统计学意义（P>0.05）；术后2周腔镜组FEV1、FEV1/FVC均高于传统组（P<0.05）；术后5d腔镜组IL-8、TNF-α、IL-10均低于传统组（P<0.05）；术后随访24个月，腔镜组的肿瘤复发率为41.18%、生存率为68.63%；而传统组分别为31.15%和73.77%。［结论］ 胸腹腔镜联合食管癌根治术对患者肺功能影响小，术后患者的炎症反应程度轻，手术效果与开胸手术相当。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the lung function，serum levels of inflammatory factors and prognosis of patients with esophageal cancer after thoracoscopy- and laparoscopy-assissted radical esophagectomy. ［Methods］ One hundred and twelve patients with esophageal cancer undergoing surgical treatment from October 2011 to December 2014 were enrolled in the study，among whom 51 cases received thoracoscopy- and laparoscopy-assisted radical esophagectomy(study group) and 61 cases received conventional thoracotomy(control group). Perioperative indicators，pulmonary function and serum inflammatory factor levels and prognosis of patients were compared between two groups. ［Results］ The operation time，intraoperative blood loss，postoperative drainage，length of hospital stay in study group were all lower than those in control group(P<0.05). There was no significant difference in the number of lymph nodes dissected between two groups(P>0.05). Two weeks after surgery，the FEV1 and FEV1/FVC in study group was higher than those in control group(P<0.05)；5 days after surgery serum IL-8，TNF-α，IL-10 levels in study group were lower than those in control group(P<0.05). During the 24-month follow-up，the recurrence rates in study group and control group were 41.18% and 31.15%; the survival reates were 68.63% and 73.77%，respectively. ［Conclusion］ The impact of endoscopy-assisted thoracic surgery on lung function and inflammation status in patients with esophageal cancer is limited. |
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