| 吴盛喜,罗何三,许鸿鹞.327例临床T4期食管癌放疗患者的疗效及预后因素分析[J].肿瘤学杂志,2017,23(12):1064-1068. |
| 327例临床T4期食管癌放疗患者的疗效及预后因素分析 |
| Response and Prognostic Factors in 327 Cases with Stage T4 Esophageal Cancer Based on Non-surgical Clinical Staging After Radiotherapy |
| 投稿时间：2017-07-19 |
| DOI：10.11735/j.issn.1671-170X.2017.12.B004 |
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| 中文关键词: 食管肿瘤 T4期 辅助化疗 放疗 预后 |
| 英文关键词:esophageal cancer stage T4 chemoradiotherapy adjuvant chemotherapy prognosis |
| 基金项目:广东省科技计划项目（2016ZC0250） |
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| 摘要点击次数: 1613 |
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| 中文摘要: |
| 摘 要： ［目的］ 分析临床T4期食管癌患者放疗的疗效及预后影响因素，探讨指导该患者人群治疗的最佳方式。［方法］ 回顾性分析接受放疗和同期放化疗的T4期食管癌患者327例，采用Kaplan-Meier法计算生存率，分析远期疗效，并采用单因素和COX多因素分析影响患者预后的因素。［结果］ 全组中位随访时间12.43个月，全组1、2、3和5年生存率分别为51.6%、22.0%、14.9%和10.3%。单因素分析显示是否行辅助化疗(P=0.004)及N分期(P=0.026)与患者预后相关；COX多因素分析显示，是否行辅助化疗(P=0.006)及N分期(P=0.029)是影响患者的独立预后因素。［结论］ 在临床T4期食管癌中，同期放化疗并不影响患者预后，是否行辅助化疗及N分期可为局部晚期T4期食管癌预后判断提供依据，指导临床实践。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the response and prognostic factors in patients with stage T4 esophageal cancer according to non-surgical clinical staging after radiotherapy，and to explore the most optimal treatment for these patients. ［Methods］ A total of 327patients who hadStage T4 esophageal cancer according to non-surgical clinical stagingand received radiotherapy and adjuvant chemoradiotherapy were retrospectively analyzed. The survival rate was calculated usingthe Kaplan-Meier method. The Cox regression model was used for invariant analysis and multivariate analysis. ［Results］ The median follow up time was 12.43 months. The 1-，2-，3-，and 5-year survival rate was 51.6%，22.0%，14.9%，and 10.3%，respectively. In univariant analysis，the use of adjuvant chemotherapy(P=0.004) and N-staging(P=0.029) was related with the prognosis of the patients havingStage T4 esophageal cancer. The COX regression model showed that adjuvant chemotherapy(P=0.006) and N-staging(P=0.026) were independent prognostic factors that affected the survival rate. ［Conclusion］ In patients who hadStage T4 esophageal cancer based on non-surgical clinical staging，concurrent chemoradiotherapy did not improve the survival rate.Adjuvant chemotherapy and N-staging could provide evidence for prognosis evaluation and clinical practice. |
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