| 秦 岩,石 岩,赵明慧.三阴性乳腺癌的分子分型及靶向治疗进展[J].肿瘤学杂志,2017,23(11):1027-1031. |
| 三阴性乳腺癌的分子分型及靶向治疗进展 |
| Progress in Molecular Type and Targeted Therapy in Triple-negative Breast Cancer |
| 投稿时间：2017-01-11 |
| DOI：10.11735/j.issn.1671-170X.2017.11.B019 |
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| 中文关键词: 三阴性乳腺癌 分子分型 靶向治疗 |
| 英文关键词:triple-negative breast cancer molecular classification targeted therapy |
| 基金项目:国家自然科学基金（31301143） |
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| 摘要点击次数: 2012 |
| 全文下载次数: 679 |
| 中文摘要: |
| 摘 要：三阴性乳腺癌(triple-negative breast cancer，TNBC )具有高度侵袭性，组织学分级较高，易发生早期复发转移，对于内分泌治疗及HER2靶向治疗往往不敏感。因此准确识别三阴性乳腺癌有效靶点及积极研制新型靶向治疗药物是临床科研中亟待解决的问题。全文就三性阴乳腺癌的分子分型及靶向治疗最新进展作一综述。 |
| 英文摘要: |
| Abstract：Triple-negative breast cancers(TNBC) usually present higher histological grade；are highly invasive and prone to metastasis at the early stage. TNBC are often not sensitive to endocrine therapy and HER2-targeted therapy. So it is crucial to accurately identify novel therapeutic targets and to develop new targeted drugs for TNBC. In this paper，the molecular classification and targeted therapy of TNBC are reviewed. |
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