| 褚玉新,胡钦勇,宋启斌.乙醛脱氢酶在肿瘤干细胞鉴定中的作用[J].肿瘤学杂志,2017,23(11):1022-1026. |
| 乙醛脱氢酶在肿瘤干细胞鉴定中的作用 |
| The Role of Aldehyde Dehydrogenase in Characterization of Cancer Stem Cells |
| 投稿时间：2017-04-05 |
| DOI：10.11735/j.issn.1671-170X.2017.11.B018 |
|
 |
| 中文关键词: 乙醛脱氢酶 肿瘤干细胞 鉴定 |
| 英文关键词:aldehyde dehydrogenase cancer stem cell characterization |
| 基金项目:国家自然科学基金资助(81372407，81670123) |
|
| 摘要点击次数: 1900 |
| 全文下载次数: 1071 |
| 中文摘要: |
| 摘 要：肿瘤干细胞被认为是肿瘤复发和转移的根源，其鉴定尤为重要。当前肿瘤干细胞鉴定的主要方法有利用干细胞表面标志鉴定、细胞增殖和分化能力的鉴定、动物体内致瘤性鉴定、化疗耐药性的鉴定、放疗抵抗性的鉴定等。乙醛脱氢酶是细胞质中调节乙醛代谢的一种重要酶类，其在肿瘤干细胞中显示出很高的活性，可作为肿瘤干细胞鉴定的标志物。研究乙醛脱氢酶在肿瘤干细胞鉴定中的作用将有利于肿瘤的诊断、治疗和预后评估。 |
| 英文摘要: |
| Abstract：Cancer stem cells (CSC) are responsible for the relapse and metastasis of cancers，so the characterization of CSC is very important. Current methods for characterizing CSC include cellular biomarker-based characterization，cell proliferation and differentiation characterization，tumorigenesis in vivo，chemo-resistance and radio-resistance characterization. Aldehyde dehydrogenase(ALDH) is an important cytosolic enzyme which regulates aldehyde metabolism. ALDH is highly active in CSC and has been regarded as a biomarker for characterization of CSC. Studying the role of ALDH in characterization of CSC will benefit the diagnosis，treatment，and prognosis evaluation of cancers. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |