| 宋晓丹,马玉梅,李永红.聚乙二醇干扰素α-2α治疗HCV/HIV共感染临床疗效[J].肿瘤学杂志,2017,23(11):1016-1018. |
| 聚乙二醇干扰素α-2α治疗HCV/HIV共感染临床疗效 |
| Anti-Viral Therapy with Pegylated Interferon Alpha-2α Plus Ribavirin in Patients with Co-Infected of HBV and HCV |
| 投稿时间：2017-02-23 |
| DOI：10.11735/j.issn.1671-170X.2017.11.B016 |
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| 中文关键词: 人类免疫缺陷病毒 丙型肝炎病毒 共感染 |
| 英文关键词:human immunodeficiency virus hepatitis C virus co infection |
| 基金项目:辽宁省建平县肝脏疾病高发综合防治科技惠民示范工程（2013GS210102）；国家自然科学基金项目（81403271） |
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| 中文摘要: |
| 摘 要：［目的］ 研究慢性丙型肝炎（CHC）与丙型肝炎病毒/人类免疫缺陷病毒（HCV/HIV）共感染者用聚乙二醇干扰素α-2a（PEG-IFNα-2a）抗病毒治疗疗效的观察。［方法］ 治疗前后定期采集30例CHC（HCV组）、30例HCV/HBV共感染者的外周血，检测HCV RNA、血常规和肝功酶谱指标。［结果］ 治疗后HCV组的HCV-RNA阴转率（73.33%）和PLT（227.13±79.34）均高于共感染组（20%、177.73±66.05），ALT、AST及APRI评分分别为（57.90±24.67、61.60±25.27、0.80±0.54）均低于共感染组（77.90±30.20、76.33±28.60、1.20±0.58）。［结论］ PEG-IFNα-2a抗病毒治疗HCV/HIV共感染者疗效较单纯丙型肝炎患者差，并且对造血系统的影响较大，建议有条件的患者应用直接抗病毒药物。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the anti-viral therapy with PEGylated interferon alpha-2α plus ribavirin in patients with co-infection of HCV and HIV. ［Methods］ Thirty patients infected with HCV (HCV group) and 30 patients co-infected with HCV and HIV (HCV/HIV group) undergoing anti-viral therapy were enrolled in the study. HCV RNA，blood and liver enzymes were examined. ［Results］ After treatment，the HCV-RNA negative conversion rate（73.33%）and PLT（227.13±79.34）of HCV group were higher than those of HCV/HIV group（20%，177.73±66.05）; and the ALT，AST and APRI scores（57.90±24.67，61.60±25.27 and 0.80±0.54） were lower than those of HCV/HIV group（77.90±30.20，76.33±28.60 and 1.20±0.58）. ［Conclusion］ The efficacy of PEG-IFN-α plus ribavirin therapy is less effective and the adverse effect for hematopoietic system is more severe in HCV/HIV co-infected patients than that in HCV patients，therefore direct-acting antiviral agents are recommended for those patients. |
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