| 展 平,谢海燕.赖氨酰氧化酶样蛋白2在肺腺癌患者中的预后价值[J].肿瘤学杂志,2017,23(11):973-977. |
| 赖氨酰氧化酶样蛋白2在肺腺癌患者中的预后价值 |
| Prognostic Value of Lysyl Oxidase-Like 2 in Patients with Lung Adenocarcinoma |
| 投稿时间：2017-07-26 |
| DOI：10.11735/j.issn.1671-170X.2017.11.B007 |
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| 中文关键词: 赖氨酰氧化酶样蛋白2 LOXL2 肺腺癌 预后 转移 |
| 英文关键词:lysyl oxidase-like 2 LOXL2 lung adenocarcinoma prognosis metastasis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨 LOXL2在肺腺癌中的表达情况及与临床病理特征预后意义。［方法］ 采用免疫组化染色（Immunohistochemical staining，IHC）的方法检测60对配对的肺腺癌及癌旁组织中LOXL2蛋白的表达水平，并根据免疫组化染色评分判断LOXL2蛋白的表达强度，分析LOXL2蛋白表达与肺腺癌临床病理特征以及预后的相关性。［结果］ LOXL2蛋白在癌组织中显著性高表达。LOXL2蛋白在肺腺癌组织中主要定位于细胞核。细胞核LOXL2高表达与肺腺癌的淋巴结转移（P=0.025）、TNM分期（P=0.031）相关，并是肺腺癌差预后的独立预测因子（P=0.028）。［结论］ 细胞核LOXL2蛋白的高表达与肺腺癌患者的差预后相关，LOXL2可以作为肺腺癌患者的一种新的预后生物指标和潜在的治疗靶点。 |
| 英文摘要: |
| Abstract：［Purpose］ To assess the prognostic value of lysyl oxidase-like 2(LOXL2) in patients with lung adenocarcinoma (AD). ［Methods］ LOXL2 protein levels were detected in 60 samples of lung AD and pericancerous lung tissues with immunohistochemical and its clinicopathologic and prognostic significance was analyzed. ［Results］ LOXL2 protein levels were higher in lung AD tissues than those in paired adjacent normal tissues. High LOXL2 levels were associated with increased lymph node metastasis and advanced p-TNM stage，LOXL2 levels were an independent prognostic factor in lung AD. ［Conclusion］ LOXL2 protein levels are associated with poor prognosis in lung AD patients. LOXL2 might serve as a prognostic biomarker and potential therapeutic target in lung AD patients. |
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