| 金 谷,夏李明,吴 昊.恶性黑色素瘤大剂量干扰素辅助治疗诱导期的耐受性观察[J].肿瘤学杂志,2017,23(11):950-954. |
| 恶性黑色素瘤大剂量干扰素辅助治疗诱导期的耐受性观察 |
| Tolerability of Patients with Maliguant Melanoma to Induction Phase of Adjuvant High-dose Interferon Therapy |
| 投稿时间：2017-01-15 |
| DOI：10.11735/j.issn.1671-170X.2017.11.B003 |
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| 中文关键词: 干扰素 恶性黑色素瘤 剂量限制性毒性 耐受性 |
| 英文关键词:interferon malignant melanoma dose-limiting toxicity tolerability |
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| 中文摘要: |
| 摘 要：［目的］ 观察恶性黑色素瘤患者术后大剂量干扰素辅助治疗诱导期的耐受性。［方法］ 回顾性分析2011年6月至2015年6月我院收治的203例AJCC ⅡB~Ⅲ期恶性黑色素瘤患者并接受术后大剂量α-2b干扰素辅助治疗，其中4周静脉诱导期剂量为1500万IU/m2，采用NCI-CTCAE 4.0评定诱导期药物相关不良事件，观察剂量限制性毒性相关事件和治疗中进展情况。［结果］ 全部203例患者诱导期均接受药物相关不良事件评价，共发生剂量限制性毒性34例次，主要为4级粒细胞减少（8.4%）和3级肝酶升高(4.4%)。21例患者遵循减量计划完成诱导，7例患者未完成诱导期治疗，原因包括3例进展，2例明显疲乏，1例重度肝功能不全和1例3级斑丘疹。1年大剂量干扰素治疗中共有42例进展，N3组复发转移率达50%。［结论］ 大剂量干扰素在中国人群中有较好的耐受性，但对于3个以上淋巴结转移的相对更高危患者，干扰素似乎有效率不高。 |
| 英文摘要: |
| Abstract：［Objective］ To observe the tolerability of patients with malignant melanoma to induction phase of adjuvant high-dose interferon therapy. ［Methods］ We retrospectively analyzed 203 cases of AJCC ⅡB~Ⅲ malignant melanoma received high-dose interferon alfa-2b in our hospital from June 2011 to June 2015. In 4 week intravenous induction phase，patients received IFN-alfa-2b at the dose of 15×106IU/m2（5 days per week） and drug-related adverse events were evaluated by NCI-CTCAE 4.0. The dose-limiting toxicity events and the progression of disease were observed. ［Results］ All 203 patients were evaluated for drug-related adverse events in the induction phase，with a total of 34 cases of dose-limiting toxicity，mainly grade 4 neutropenia (8.4%) and grade 3 liver enzyme elevation (4.4%). Twenty-one patients followed the reduction schedule and 7 patients discontinued the therapy in the induction phase，including 3 progression，2 with significant fatigue，1 with severe hepatic insufficiency，and 1 with grade 3 maculopapular rash. There were 42 cases developed disease progression during the high-dose interferon therapy and the progression rate in the N3 group was 50%. ［Conclusion］ High dose interferon alfa-2b can be well tolerated by Chinese patients，but interferon appears to be inefficient in patients with relatively higher risk of more than three lymph node metastases. |
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