| 徐振国,聂春磊,张杰武.PD-1/PD-L1在甲状腺癌中的作用及机制研究进展[J].肿瘤学杂志,2017,23(10):899-903. |
| PD-1/PD-L1在甲状腺癌中的作用及机制研究进展 |
| Research Progress in the Role and Mechanism of PD-1/PD-L1 in Thyroid Carcinoma |
| 投稿时间：2017-02-21 |
| DOI：10.11735/j.issn.1671-170X.2017.10.B013 |
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| 中文关键词: PD-1/PD-L1 甲状腺癌 分子通路 侵袭性 |
| 英文关键词:PD-1/PD-L1 thyroid cancer molecular pathway invasiveness |
| 基金项目:海燕科研基金（省科技厅公关计划）（JJZD2017-03） |
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| 中文摘要: |
| 摘 要：肿瘤细胞中表达的程序性死亡配体（PD-L1）是新兴的生物标志物，它在抗肿瘤免疫治疗中具有非常重要的作用。程序性死亡受体1(programmed cell death-1，PD-1)与其配体PD-L1属于CD28/B7家族，是一对共刺激分子，具有负性调控作用。最新研究发现，PD-L1 与PD-1的异常表达与多种癌症的发生、侵袭、转移相关。全文就PD-1/PD-L1生物学作用以及其在甲状腺癌的发生、发展中的机制研究进展、PD-1/PD-L1信号通路抑制剂及其未来在甲状腺癌靶向治疗应用前景进行综述。 |
| 英文摘要: |
| Abstract：Programmed cell death-ligand 1(PD-L1) expressed in tumor cells is a emerging biomarker，playing a pivotal role in anti-tumor immunotherapy. Programmed cell death-1(PD-1)and its ligand PD-L1，belonging to CD28/B7 family，are a pair of costimulatory molecules with function to negative regulate immune response to tumor. The latest studies have found that the abnomal expression of PD-L1 and PD-1 is associated with the occurrence，invasion，and metastasis of various malignant tumors. In this paper，we reviewed the biological function of PD-1/PD-L1 and its mechanism in the occurrence and progression of thyroid carcinoma，with a special focus on PD-1/PD-L1 signaling pathway inhibitor and its application in thyroid cancer targeted therapy in the future. |
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