| 李洁茹,孙雷雷,马怀幸.胰腺癌患者体重丢失对预后影响的系统评价[J].肿瘤学杂志,2017,23(10):877-884. |
| 胰腺癌患者体重丢失对预后影响的系统评价 |
| Relationship Between Weight Loss and Prognosis in Patients with Pancreatic Cancer：A Systematic Review |
| 投稿时间：2017-02-08 |
| DOI：10.11735/j.issn.1671-170X.2017.10.B009 |
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| 中文关键词: 胰腺癌 体重丢失 预后 临床特征 系统评价 |
| 英文关键词:pancreatic cancer weight loss prognosis clinical characteristics systematic review |
| 基金项目:安徽省自然科学基金项目（1508085MH176） |
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| 摘要点击次数: 1790 |
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| 中文摘要: |
| 摘 要：［目的］ 采用系统评价的方法探索体重丢失对胰腺癌患者预后及相关临床特征的影响。［方法］ 检索Pubmed、SCI-Ex-panded、Embase、Cochrane图书馆、中国期刊全文数据库（CNKI）、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库（VIP）及万方数据知识服务平台（Wanfang Data Knowledge Service Platform）中有关体重丢失与胰腺癌患者预后及临床特征关系的文献；根据NOS文献质量评估标准评估纳入文献质量；采用RevMan5.3软件进行数据综合；根据异质性大小决定采用固定或随机效应模型；同时对未纳入meta分析的文献进行描述分析。［结果］ 共18篇文献符合纳入标准，6篇（861例）可行meta分析。其中体重丢失≥10%的患者（188例）与体重丢失<10%的患者（264例）相比，两组OS的合并风险比（hazard ratio，HR）为2.66（95%CI：1.49~4.76，P=0.0009；异质性P=0.009，I2=74 %）；体重丢失≥5%的290例患者与体重丢失<5%的181例患者相比，两组OS的合并HR为1.83（95%CI：0.61~5.47，P=0.28；异质性P<0.00001，I2=94 %）；研究同时指出体重丢失与患者的PFS、MST、生存率、住院时间及肿瘤临床特征也有一定的相关性。［结论］ 较大程度的体重丢失将缩短胰腺癌患者的OS，影响患者的PFS、MST、住院时间、肿瘤临床特征及机体功能状态等。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the impact of weight loss on prognosisand related clinical characteristics in pancreatic cancer patientsby systematic reviewmethod. ［Methods］ Literatures on the relationship between weight loss and prognosis and clinical characteristics of patients with pancreatic cancer were obtained by retrievingPubmed，SCI-Ex-panded，Embase，the Cochrane library，China National Knowledge Infrastructure(CNKI)，Chinese Biomedical Database(CBM)，Science and Technology Periodical database(VIP) and Wanfang Data Knowledge Service Platform.The quality assessment was conducted on the basis of the Newcastle-Ottawa Quality Assessment Scale(NOS). The data synthesis were performed with RevMan 5.3. A fixed-effect or random effects model was adopted according to heterogeneity. We described the included studies which can’t be integrated in this review. ［Results］ A total of 18 studies met the inclusion criteria，meta-analysis was performed in six studies(861 cases)The patients who lost their weight ≥10%(188cases) were compared with the patients who lost their weight<10%(264 cases)，the pooled hazard ratio(HR) for OS was 2.66(95%CI：1.49~4.76，P=0.0009；heterogeneity：P=0.009，I2=74%).The 290 cases who lost their weight≥5% were compared with the patients who lost their weight<5%(181 cases)，the pooled HR for OS was 1.83(95%CI：0.61~5.47，P=0.28；heterogeneity：P<0.00001，I2=94%). Weight loss was also correlated with patients’ PFS，MST，survival rate，length of stay and clinical characteristics. ［Conclusion］ Much serious weight loss will shorten the OS of patients with pancreatic cancer，affecting their PFS，MST，length of stay，clinical features，and functional status of body. |
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