| 傅洁婷,舒锦尔,潘江峰.脑胶质瘤氢质子磁共振波谱代谢物与Ki-67抗原的相关性及其应用价值[J].肿瘤学杂志,2017,23(10):842-847. |
| 脑胶质瘤氢质子磁共振波谱代谢物与Ki-67抗原的相关性及其应用价值 |
| Correlation of Ki-67 Expression with Metabolites Detected with 1H-MR Spectroscopy in Gliomas |
| 投稿时间：2016-08-01 |
| DOI：10.11735/j.issn.1671-170X.2017.10.B002 |
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| 中文关键词: 胶质瘤 氢质子磁共振波谱成像 Cho/NAA Ki-67 |
| 英文关键词:glioma 1H-MRspectroscopy Cho/NAA Ki-67 |
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| 摘要点击次数: 1837 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胶质瘤氢质子磁共振波谱（1-H magnetic resonance spectroscopy，1H-MRS）所示代谢物值与Ki-67抗原的相关性及其应用价值。［方法］ 回顾性分析83例术前行1H-MRS检查、术后病理学结果为脑胶质瘤的患者资料，对比分析胶质瘤实质部位主要代谢物N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）及其比值（Cho/Cr、Cho/NAA、NAA/Cr）与Ki-67表达的相关性。［结果］ Cho/Cr、Cho/NAA比值与Ki-67表达呈正相关(r=0.257，P=0.019；r=0.329，P=0.002)，NAA/Cr比值与Ki-67表达呈负相关(r=-0.206，P=0.049)；Lip出现率与Ki-67表达呈正相关（r=0.304，P=0.005）。［结论］ 1H-MRS检查的各代谢物值与Ki-67表达关系密切，可有效反应脑胶质瘤的增殖活性，其中Cho/NAA比值的诊断价值最高。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the correlation of Ki-67 expression with metabolites detected with 1H-MR spectroscopy(1H-MRS) in gliomas. ［Methods］ 1H-MRS examination was performed in 83 patients with gliomas before surgery and the diagnosis was confirmed pathologically. The ratios of choline(Cho)/N-acetylaspartate(NAA)，cho/creatine(Cr)，NAA/Cr，and the occurrence rates of lactate(Lac) and lipid(Lip) signals were detected by 1HMRS. The correlation of Ki-67 expression with above metabolites was analyzed. ［Results］ The Ki-67 expression was positively correlated with Cho/Cr，Cho/NAA ratios and Lip signal occurrence rate(r=0.257，P=0.019；r=0.329，P=0.002；r=0.304，P=0.005)，and it was negatively correlated with NAA/Cr ratio(r=-0.206，P=0.049). ［Conclusion］ The metabolites detected by 1-HMRS are closely correlated with Ki-67 expression in gliomas，suggesting that some metabolites(especially Cho/NAA) may indicate the tumors proliferation activity in glioma before the operation. |
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