| 黄 维,夏百荣,娄 阁.MiR-200家族在卵巢癌中的研究进展[J].肿瘤学杂志,2017,23(9):812-815. |
| MiR-200家族在卵巢癌中的研究进展 |
| Research Progress of MiR-200 Family in Ovarian Cancer |
| 投稿时间：2016-11-18 |
| DOI：10.11735/j.issn.1671-170X.2017.09.B015 |
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| 中文关键词: miR-200家族 卵巢癌 转移 化疗 诊断 预后 |
| 英文关键词:ovarian cancer miR-200 family metastasis chemotherapy diagnosis prognosis |
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| 摘要点击次数: 1966 |
| 全文下载次数: 465 |
| 中文摘要: |
| 摘 要：微小RNA（miRNA）是一种内源性的、长约22个核苷酸的非编码小 RNA。通过在转录后水平降解靶 mRNA或者抑制靶基因的表达而参与调控细胞的生长、增殖和凋亡等。研究表明miR-200家族与卵巢癌发展、转移、耐药及预后密切相关，有望为卵巢癌的诊治提供新的思路。全文就miR-200家族在卵巢癌中作用的研究进展进行综述。 |
| 英文摘要: |
| Abstract：MicroRNA，a short non-coding sequence of an endogenous small RNA of 21~23 nucleotides in length，are participating in regulating cell growth，proliferation and apoptosis by post-transcriptional degrading mRNA or inhibiting target genes. Studies confirm that miR-200 family are significantly correlated with development，metastasis，chemotherapy resistance and prognosis of ovarian cancer，providing ovarian cancer with new detection and treatment method. In our article，we mainly reviews the function of miR-200 family in ovarian cancer. |
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