董 熠,李祥攀,宋启斌.CDK4/6抑制剂联合内分泌治疗晚期乳腺癌研究进展[J].肿瘤学杂志,2017,23(9):807-811. |
CDK4/6抑制剂联合内分泌治疗晚期乳腺癌研究进展 |
Research Progress on Cyclin-dependent Kinase 4 and 6 Combined with Endocrine Treatment in Breast Cancer |
投稿时间:2017-01-11 |
DOI:10.11735/j.issn.1671-170X.2017.09.B014 |
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中文关键词: 乳腺癌 细胞周期 周期蛋白依赖性激酶 内分泌治疗 |
英文关键词:breast cancer cell cycle cyclin-dependent kinase endocrine treatment |
基金项目:国家自然科学基金(81372407);湖北省自然基金(2014CFB394);湖北省卫计委项目(WJ2017M027) |
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中文摘要: |
摘 要:近年来,多项研究显示细胞周期蛋白依赖性激酶4和6( CDK4/6) 抑制剂对于激素受体阳性晚期乳腺癌患者具有较好的疗效,甚至可改善内分泌耐药问题。相关研究表明CDK4/6抑制剂联合内分泌治疗在临床应用中极具前景。 |
英文摘要: |
Abstract:Recently,cyclin-dependent kinase 4 and 6(CDK4/6) inhibitors are identified to be useful in breast cancer patients with positive estrogen receptor,and could improve the efficacy of endocrine therapy against HR+ breast cancer. The ongoing studies confirm the benefits and tolerability of CDK 4/6 inhibition,and the combination therapy with endocrine agents may become a new standard for breast cancer. |
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